Publication Name	World Journal of Gastroenterology
Manuscript ID	23576
Country	Mexico

Received	2015-12-02 08:27
Peer-Review Started	2015-12-04 09:51
First Decision by Editorial Office Director
Return for Revision	2015-12-31 10:24
Revised	2016-01-19 04:06
Publication Fee Transferred
Second Decision by Editor	2016-01-21 08:54
Second Decision by Editor-in-Chief	2016-01-21 16:03
Final Decision by Editorial Office Director	2016-01-30 17:33
Articles in Press	2016-01-30 17:33
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-18 17:00
Publish the Manuscript Online	2016-05-04 10:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Peer-review started: February 25, 2016
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pathology
Manuscript Type	Retrospective Study
Article Title	Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia
Manuscript Source	Unsolicited Manuscript
All Author List	Roberto Herrera-Goepfert, Luis F Oñate-Ocaña, José Luis Mosqueda-Vargas, Luis A Herrera, Clementina Castro, Julia Mendoza and Rodrigo González-Barrios
Funding Agency and Grant Number
Corresponding Author	Roberto Herrera-Goepfert, MD, Department of Pathology, Instituto Nacional de Cancerología (INCan), México, Av. San Fernando 22, Colonia Sección XVI, Delegación Tlalpan, 10480 México, DF, México. rhgoepfert@gmail.com
Key Words	DNA methylation; Esophageal columnar metaplasia; Thrombospondin-1; Death-associated protein kinase; Helicobacter pylori; cagA
Core Tip	Columnar metaplasia of the esophagus, whether specialized or not, is a hallmark of gastroesophageal reflux disease. Current information suggests that intestinal metaplasia in the esophagus arises from gastric-type metaplasia. In this study, we have demonstrated that Helicobacter pylori (H. pylori) cagA+ can colonize esophageal gastric-type metaplastic mucosa, and that DNA methylation of tumor suppressor genes could be related to H. pylori cagA+ infection, which in turn, may predispose to precancerous lesions, including intestinal metaplasia.
Publish Date	2016-05-04 10:08
Citation	Herrera-Goepfert R, Oñate-Ocaña LF, Mosqueda-Vargas JL, Herrera LA, Castro C, Mendoza J, González-Barrios R. Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia. World J Gastroenterol 2016; 22(18): 4567-4575
URL	http://www.wjgnet.com/1007-9327/full/v22/i18/4567.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i18.4567

Full Article (PDF)	WJG-22-4567.pdf
Full Article (Word)	WJG-22-4567.doc
Manuscript File	23576-Review.docx
Answering Reviewers	23576-Answering reviewers.pdf
Audio Core Tip	23576-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	23576-Conflict-of-interest statement.pdf
Copyright License Agreement	23576-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	23576-Institutional review board statement.pdf
Peer-review Report	23576-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23576-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23576-Scientific misconduct check.pdf
Scientific Editor Work List	23576-Scientific editor work list.pdf