Publication Name	World Journal of Gastroenterology
Manuscript ID	23580
Country	Finland

Received	2015-12-03 08:51
Peer-Review Started	2015-12-04 10:32
To Make the First Decision	2015-12-31 08:50
Return for Revision	2015-12-31 10:04
Revised
Second Decision	2016-02-26 18:18
Accepted by Journal Editor-in-Chief	2016-02-26 18:30
Accepted by Company Editor-in-Chief	2016-03-02 10:33
Articles in Press	2016-03-02 10:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-05 15:45
Publish the Manuscript Online	2016-04-29 16:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Tarja Ruuska, Peter Küster, Lena Grahnquist, Fredrik Lindgren and Anne Vibeke Wewer
Funding Agency and Grant Number	Funding Agency Grant Number Otsuka Frankfurt Research Institute, Otsuka Pharmaceutical Europe Ltd.
Corresponding Author	Tarja Ruuska, MD, Department of Pediatrics, Tampere University Hospital, 33521 Tampere, Finland. tarja.ruuska@pshp.fi
Key Words	Granulocyte-monocyte apheresis; Pediatric; Ulcerative colitis; Inflammatory bowel disease; Therapy; Steroids; Clinical trial
Core Tip	For a considerable group of children with ulcerative colitis (UC), treatment options are limited especially after failure of conventional treatment. The ADAPT trial was designed to generate prospective cohort data on efficacy and safety levels in moderate active pediatric UC patients when treated with Adacolumn granulocyte, mono-cyte/macrophage adsorptive (GMA). The present data contribute to considering GMA apheresis as a therapeutic option in pediatric patients having failed first line therapy.
Publish Date	2016-04-29 16:50
Citation	Ruuska T, Küster P, Grahnquist L, Lindgren F, Wewer AV. Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis. World J Gastroenterol 2016; 22(17): 4389-4396
URL	http://www.wjgnet.com/1007-9327/full/v22/i17/4389.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i17.4389

Full Article (PDF)	WJG-22-4389.pdf
Full Article (Word)	WJG-22-4389.doc
Manuscript File	23580-Review.docx
Answering Reviewers	23580-Answering reviewers.pdf
Audio Core Tip	23580-Audio core tip.mp3
Biostatistics Review Certificate	Biostatistics_Statement_20151202173721.pdf
Clinical Trial Registration Statement	23580-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	23580-Conflict-of-interest statement.pdf
Copyright License Agreement	23580-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	23580-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	23580-Institutional review board statement.pdf
Peer-review Report	23580-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23580-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23580-Scientific misconduct check.pdf
Scientific Editor Work List	23580-Scientific editor work list.pdf