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Articles Published Processes
5/30/2016 5:39:00 PM | Browse: 1519 | Download: 7193
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Received |
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2015-12-04 09:01 |
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Peer-Review Started |
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2015-12-04 14:10 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-02-20 15:05 |
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Revised |
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2016-02-24 18:27 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-03-04 18:06 |
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Second Decision by Editor-in-Chief |
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2016-03-05 09:46 |
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Final Decision by Editorial Office Director |
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2016-03-14 09:38 |
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Articles in Press |
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2016-03-14 10:44 |
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Edit the Manuscript by Language Editor |
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2016-04-14 07:57 |
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Typeset the Manuscript |
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2016-05-03 10:48 |
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Publish the Manuscript Online |
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2016-05-30 17:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun Qian, Elsie Oppermann, Andreas Tran, Ulli Imlau, Kun Qian and Thomas Josef Vogl |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81071241 |
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| Corresponding Author |
Thomas Josef Vogl, PhD, Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University, D-60590 Frankfurt am Main, Germany. t.vogl@em.uni-frankfurt.de |
| Key Words |
Hepatocellular carcinoma; Transarterial chemoembolization; Integrin inhibitor; Nanoparticles; Matrix metalloprotein 9; Vascular endothelial growth factor; ACI rats |
| Core Tip |
Our experimental study was designed to reduce tumor progression and recurrence through a combination of transarterial administration of GRGDSP (integrin-inhibitor) loaded nanoparticles plus transarterial chemoembolization (TACE) in an animal model of liver tumor. Our data showed that the combined biological and interventional treatment is a safe and effective therapy compared with TACE alone or TACE plus GRGDSP. The combined multimodal targeting therapies exhibit tremendous advantages over conventional interventional therapy alone. |
| Publish Date |
2016-05-30 17:40 |
| Citation |
Qian J, Oppermann E, Tran A, Imlau U, Qian K, Vogl TJ. Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model. World J Gastroenterol 2016; 22(21): 5042-5049 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i21/5042.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i21.5042 |
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