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Articles Published Processes
5/4/2016 10:08:00 AM | Browse: 1054 | Download: 2200
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Received |
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2015-12-29 09:35 |
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Peer-Review Started |
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2015-12-29 14:24 |
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To Make the First Decision |
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2016-01-28 15:05 |
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Return for Revision |
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2016-01-29 17:46 |
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Revised |
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2016-02-27 12:40 |
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Second Decision |
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2016-03-11 16:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-03-18 17:43 |
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Articles in Press |
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2016-03-18 17:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-03-28 08:18 |
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Typeset the Manuscript |
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2016-04-07 09:05 |
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Publish the Manuscript Online |
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2016-05-04 10:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Peer-review started: February 25, 2016 |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Basic Study |
| Article Title |
Role of estrogen receptor β selective agonist in ameliorating portal hypertension in rats with CCl4-induced liver cirrhosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cheng-Gang Zhang, Bin Zhang, Wen-Sheng Deng, Ming Duan, Wei Chen and Zhi-Yong Wu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation for the Youth of China |
81400630 |
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| Corresponding Author |
Zhi-Yong Wu, MD, PhD, Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1630 Dongfang Road, Shanghai 200127, China. zhiyongwu1949@sina.com |
| Key Words |
Portal hypertension; Estrogen receptor; Rho-kinase signaling; Nitric oxide; Hepatic stellate cells |
| Core Tip |
Liver cirrhosis and portal hypertension (PHT) are subject to gender and estrogen levels. The aim of the present study was to investigate whether estrogen receptor β selective agonists could ameliorate intrahepatic resistance and mitigate PHT in rats with CCl4-induced cirrhosis, and uncover the underlying mechanism by investigating RhoA/ROCK and NO/PKG signaling. The authors propose that treatment with an estrogen receptor β selective agonist could improve cirrhotic PHT via regulating RhoA/ROCK and NO/PKG signaling. |
| Publish Date |
2016-05-04 10:08 |
| Citation |
Zhang CG, Zhang B, Deng WS, Duan M, Chen W, Wu ZY. Role of estrogen receptor β selective agonist in ameliorating portal hypertension in rats with CCl4-induced liver cirrhosis. World J Gastroenterol 2016; 22(18): 4484-4500 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i18/4484.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i18.4484 |
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