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Articles Published Processes
4/29/2016 4:50:00 PM | Browse: 1266 | Download: 2534
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Received |
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2015-12-07 15:11 |
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Peer-Review Started |
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2015-12-07 17:14 |
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To Make the First Decision |
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2016-01-28 15:05 |
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Return for Revision |
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2016-01-29 18:27 |
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Revised |
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2016-02-25 12:24 |
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Second Decision |
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2016-03-04 18:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-03-14 09:44 |
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Articles in Press |
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2016-03-14 09:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-03-18 08:49 |
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Typeset the Manuscript |
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2016-03-23 15:10 |
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Publish the Manuscript Online |
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2016-04-29 16:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Activation of AMPK/MnSOD signaling mediates anti-apoptotic effect of hepatitis B virus in hepatoma cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lei Li, Hong-Hai Hong, Shi-Ping Chen, Cai-Qi Ma, Han-Yan Liu and Ya-Chao Yao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Nature Science Foundation of China |
81400639 |
| National Nature Science Foundation of China |
81502507 |
| Doctoral Starting Up Foundation of Guangzhou Medical University of China |
2014C39 |
| Science Foundation for Youth Scientists of the Second People’s Hospital of Guangdong Province of China |
YQ2015-002 |
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| Corresponding Author |
Ya-Chao Yao, PhD, Department of Clinical Laboratory Medicine, the Second People’s Hospital of Guangdong Province, No. 466 Xinggangzhonglu, Haizhu District, Guangzhou 510317, Guangdong Province,
China. yaoyachaoll@163.com |
| Key Words |
Hepatitis B virus; Reactive oxygen species; Apoptosis; Manganese superoxide dismutase; AMP-activated protein kinase |
| Core Tip |
Hepatitis B virus markedly protected the cells from growth suppression and cell death in the condition of serum deprivation. A decrease of superoxide anion production accompanied with an increase of manganese superoxide dismutase (MnSOD) expression and activity was found in HepG2.215 cells. Moreover, AMP-activated protein kinase activation contributed to the up-regulation of MnSOD. Hepatitis B virus X protein was identified to promote the expression of AMPK and MnSOD.
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| Publish Date |
2016-04-29 16:50 |
| Citation |
Li L, Hong HH, Chen SP, Ma CQ, Liu HY, Yao YC. Activation of AMPK/MnSOD signaling mediates anti-apoptotic effect of hepatitis B virus in hepatoma cells. World J Gastroenterol 2016; 22(17): 4345-4353 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i17/4345.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i17.4345 |
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