Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	23651
Country	Ireland

Received	2016-01-08 08:49
Peer-Review Started	2016-01-09 14:25
To Make the First Decision	2016-02-26 18:11
Return for Revision	2016-02-29 10:05
Revised	2016-04-06 00:00
Second Decision	2016-05-09 18:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-05-27 11:11
Articles in Press	2016-05-27 11:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-26 15:13
Publish the Manuscript Online	2016-08-09 08:50

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Surgery
Manuscript Type	Observational Study
Article Title	Activated systemic inflammatory response at diagnosis reduces lymph node count in colonic carcinoma
Manuscript Source	Invited Manuscript
All Author List	Rory P Kennelly, Brenda Murphy, John O Larkin, Brian J Mehigan and Paul H McCormick
Funding Agency and Grant Number
Corresponding Author	Rory P Kennelly, Department of Colorectal Surgery, St. James Hospital, James’s Street, Dublin 8, Ireland. rorykennelly@rcsi.ie
Key Words	Systemic inflammatory response; Lymph node yield; Lymph node count; Colon cancer; Colonic cancer; Neutrophil-lymphocyte ratio; Neutrophil to lymphocyte ratio; Lymph node ratio
Core Tip	A fascinating field of research is the relationship between systemic inflammatory response and loco-regional inflammatory response in colorectal cancer. This manuscript examines this relationship in a large cohort of patients from a tertiary referral centre. We measured systemic response by assessing serum markers at diagnosis and we measured local response by looking at pathological lymph node counts in the post operative surgical specimen. This is the first report to show that patients with evidence of an activated systemic inflammatory response at diagnosis have a reduced nodal harvest at time of surgery. This finding sheds light on the complex interaction between cancer and the patient. This host-tumour response forms the basis for the most advanced cancer research today.
Publish Date	2016-08-09 08:50
Citation	Kennelly RP, Murphy B, Larkin JO, Mehigan BJ, McCormick PH. Activated systemic inflammatory response at diagnosis reduces lymph node count in colonic carcinoma. World J Gastrointest Oncol 2016; 8(8): 623-628
URL	http://www.wjgnet.com/1948-5204/full/v8/i8/623.htm
DOI	http://dx.doi.org/10.4251/wjgo.v8.i8.623

Full Article (PDF)	WJGO-8-623.pdf
Full Article (Word)	WJGO-8-623.doc
Manuscript File	23651-Review.doc
Answering Reviewers	23651-Answering reviewers.pdf
Audio Core Tip	23651-Audio core tip.wma
Biostatistics Review Certificate	23651-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	23651-Conflict-of-interest statement.pdf
Copyright License Agreement	23651-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	23651-Institutional review board statement.pdf
Peer-review Report	23651-Peer-review(s).pdf
Scientific Misconduct Check	23651-Scientific misconduct check.pdf
Scientific Editor Work List	23651-Scientific editor work list.pdf