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8/9/2016 8:46:00 AM | Browse: 743 | Download: 1121
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 23651
Country/Territory Ireland
Received
2016-01-08 08:49
Peer-Review Started
2016-01-09 14:25
To Make the First Decision
2016-02-26 18:11
Return for Revision
2016-02-29 10:05
Revised
2016-04-06 00:00
Second Decision
2016-05-09 18:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-05-27 11:11
Articles in Press
2016-05-27 11:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-07-26 15:13
Publish the Manuscript Online
2016-08-09 08:50
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Surgery
Manuscript Type Observational Study
Article Title Activated systemic inflammatory response at diagnosis reduces lymph node count in colonic carcinoma
Manuscript Source Invited Manuscript
All Author List Rory P Kennelly, Brenda Murphy, John O Larkin, Brian J Mehigan and Paul H McCormick
Funding Agency and Grant Number
Corresponding Author Rory P Kennelly, Department of Colorectal Surgery, St. James Hospital, James’s Street, Dublin 8, Ireland. rorykennelly@rcsi.ie
Key Words Systemic inflammatory response; Lymph node yield; Lymph node count; Colon cancer; Colonic cancer; Neutrophil-lymphocyte ratio; Neutrophil to lymphocyte ratio; Lymph node ratio
Core Tip A fascinating field of research is the relationship between systemic inflammatory response and loco-regional inflammatory response in colorectal cancer. This manuscript examines this relationship in a large cohort of patients from a tertiary referral centre. We measured systemic response by assessing serum markers at diagnosis and we measured local response by looking at pathological lymph node counts in the post operative surgical specimen. This is the first report to show that patients with evidence of an activated systemic inflammatory response at diagnosis have a reduced nodal harvest at time of surgery. This finding sheds light on the complex interaction between cancer and the patient. This host-tumour response forms the basis for the most advanced cancer research today.
Publish Date 2016-08-09 08:50
Citation Kennelly RP, Murphy B, Larkin JO, Mehigan BJ, McCormick PH. Activated systemic inflammatory response at diagnosis reduces lymph node count in colonic carcinoma. World J Gastrointest Oncol 2016; 8(8): 623-628
URL http://www.wjgnet.com/1948-5204/full/v8/i8/623.htm
DOI http://dx.doi.org/10.4251/wjgo.v8.i8.623
Full Article (PDF) WJGO-8-623.pdf
Full Article (Word) WJGO-8-623.doc
Manuscript File 23651-Review.doc
Answering Reviewers 23651-Answering reviewers.pdf
Audio Core Tip 23651-Audio core tip.wma
Biostatistics Review Certificate 23651-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 23651-Conflict-of-interest statement.pdf
Copyright License Agreement 23651-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 23651-Institutional review board statement.pdf
Peer-review Report 23651-Peer-review(s).pdf
Scientific Misconduct Check 23651-Scientific misconduct check.pdf
Scientific Editor Work List 23651-Scientific editor work list.pdf