Publication Name	World Journal of Gastroenterology
Manuscript ID	23696
Country	Greece

Received	2015-12-11 08:44
Peer-Review Started	2015-12-11 10:34
First Decision by Editorial Office Director
Return for Revision	2016-01-13 13:28
Revised	2016-01-18 20:43
Publication Fee Transferred
Second Decision by Editor	2016-01-28 14:13
Second Decision by Editor-in-Chief	2016-01-28 15:39
Final Decision by Editorial Office Director	2016-02-22 11:02
Articles in Press	2016-02-22 11:03
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-16 11:27
Publish the Manuscript Online	2016-04-03 18:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia
Manuscript Source	Invited Manuscript
All Author List	Alexandra Alexopoulou, Larisa Vasilieva, Danai Agiasotelli, Kyriaki Siranidi, Sophia Pouriki, Athanasia Tsiriga, Marina Toutouza and Spyridon P Dourakis
Funding Agency and Grant Number
Corresponding Author	Dr. Alexandra Alexopoulou, MD, Assistant Professor of Medicine, 2nd Department of Internal Μedicine, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, 114 Vas Sophias St, 11527 Athens, Greece. alexopou@ath.forthnet.gr
Key Words	Spontaneous bacterial peritonitis; Spon­taneous bacteremia; Multidrug-resistant bacteria; Extensively drug-resistant bacteria; Susceptibility to antibiotics
Core Tip	This is a prospective, observational, single Center study seeking to evaluate the epidemiology and outcomes of 130 patients with decompensated cirrhosis and culture-positive spontaneous bacterial peritonitis or spontaneous bacteremia. Both multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacteria were isolated in about one third of the cases. Patients with XDR demonstrated high mortality compared to the rest of the patients. All MDR/XDR associated infections were health-care associated and/or nosocomial. Independent factors adversely affected survival included XDR infection, renal dysfunction and coagulation disorder.
Publish Date	2016-04-03 18:51
Citation	Alexopoulou A, Vasilieva L, Agiasotelli D, Siranidi K, Pouriki S, Tsiriga A, Toutouza M, Dourakis SP. Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia. World J Gastroenterol 2016; 22(15): 4049-4056
URL	http://www.wjgnet.com/1007-9327/full/v22/i15/4049.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i15.4049

Full Article (PDF)	WJG-22-4049.pdf
Full Article (Word)	WJG-22-4049.doc
Manuscript File	23696-Review.doc
Answering Reviewers	23696-Answering reviewers.pdf
Audio Core Tip	23696-Audio core tip.mp3
Biostatistics Review Certificate	23696-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	23696-Conflict-of-interest statement.pdf
Copyright License Agreement	23696-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20151210204953.pdf
Institutional Review Board Approval Form or Document	23696-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	23696-Journal editor-in-chief review report.pdf
Peer-review Report	23696-Peer-review(s).pdf
Scientific Misconduct Check	23696-Scientific misconduct check.pdf
Scientific Editor Work List	23696-Scientific editor work list.pdf