Publication Name	World Journal of Respirology
Manuscript ID	2371
Country	Czech Republic

Received	2013-02-18 10:18
Peer-Review Started	2013-02-19 16:49
To Make the First Decision	2013-03-11 15:09
Return for Revision	2013-03-17 15:34
Revised	2013-04-06 06:16
Second Decision	2013-05-16 20:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-05-17 09:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-23 19:23
Publish the Manuscript Online	2013-06-08 09:56

ISSN	2218-6255 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Respiratory System
Manuscript Type	Autobiography
Article Title	Cytokine gene polymorphisms in idiopathic pulmonary fibrosis
Manuscript Source	Invited Manuscript
All Author List	Martina Vasakova, Martina Sterclova, Libor Kolesar, Antonij Slavcev, Jelena Skibova, Martina Langova and Ilja Striz
Funding Agency and Grant Number	Funding Agency Grant Number Internal Grant Agency of Ministry of Health of the Czech Republic 9131-3/2007 Internal Grant Agency of Ministry of Health of the Czech Republic NS 10423-3/2009 Internal Grant Agency of Ministry of Health of the Czech Republic NT 13433-4/2012
Corresponding Author	Martina Vasakova, MD, PhD, Associate Professor, Department of Respiratory Medicine, 1st Medical School Charles University and Thomayer Hospital, Prague, Videnska 800, 14059 Prague 4, Czech Republic. martina.vasakova@ftn.cz
Key Words	Cytokine genes; Idiopathic pulmonary fibrosis; TH2-type immune response
Core Tip	Enhanced fibroproliferation resulting in terminal fibrosis is the main feature of idiopathic pulmonary fibrosis (IPF). Various mechanisms of alveolar damage and its healing are involved in IPF development. One of the potential contributing pathogenic factors is the genetically encoded imbalance of cytokine production. We found differences between the frequencies of interleukin (IL)-4 gene promoter polymorphisms in IPF patients vs controls. Based on these results and on the observation that IL-4 promoter polymorphisms can influence IL-4 production, we hypothesize that IL-4 promoter polymorphisms could be involved in the pathogenesis of IPF, likely by enhancing the TH2 cytokine milieu with subsequent fibroproliferative healing.
Publish Date	2013-06-08 09:56
Citation	Vasakova M, Sterclova M, Kolesar L, Slavcev A, Skibova J, Langova M, Striz I. Cytokine gene polymorphisms in idiopathic pulmonary fibrosis. World J Respirol 2013; 3(1): 1-7
URL	http://www.wjgnet.com/2218-6255/full/v3/i1/1.htm
DOI	http://dx.doi.org/10.5320/wjr.v3.i1.1

Full Article (PDF)	WJR-3-1.pdf
Manuscript File	2371-Review.doc
Answering Reviewers	2371-Answering reviewers.pdf
Copyright License Agreement	2371-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2371-Language certificate.pdf
Peer-review Report	2371-Peer review(s).pdf
Scientific Editor Work List	2371-Scientific editor work list.doc