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Articles Published Processes
5/19/2016 9:54:00 AM | Browse: 984 | Download: 2112
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Received |
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2016-01-09 13:09 |
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Peer-Review Started |
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2016-01-09 14:33 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-02-18 14:49 |
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Revised |
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2016-03-03 23:26 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-03-17 14:32 |
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Second Decision by Editor-in-Chief |
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2016-03-17 18:46 |
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Final Decision by Editorial Office Director |
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2016-04-07 16:01 |
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Articles in Press |
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2016-04-07 16:01 |
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Edit the Manuscript by Language Editor |
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2016-04-17 10:52 |
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Typeset the Manuscript |
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2016-04-25 13:42 |
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Publish the Manuscript Online |
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2016-05-17 10:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Qinggan Huoxue Recipe suppresses epithelial-to-mesenchymal transition in alcoholic liver fibrosis through TGF-β1/Smad signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tao Wu, Jun-Ming Chen, Tie-Gang Xiao, Xiang-Bing Shu, Han-Chen Xu, Li-Li Yang, Lian-Jun Xing, Pei-Yong Zheng and Guang Ji |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81202979 |
| Shanghai Rising-Star Program |
15QA1403500 |
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| Corresponding Author |
Guang Ji, MD, PhD, Professor, Director, Institute of Digestive Disease, China-Canada Center of Research for Digestive Diseases (ccCRDD), Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping Road, Shanghai 200032, China. jiliver@vip.sina.com
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| Key Words |
Alcoholic liver fibrosis; QGHXR; Epithelial-to-mesenchymal transition; Snail; Transforming growth factor-β1/Smad |
| Core Tip |
Epithelial-to-mesenchymal transition (EMT) is a dynamic process by which mature epithelial cells lose their distinct characteristics and acquire a mesenchymal phenotype. EMT is characterized by loss of the expression of the epithelial marker E-cadherin and up-regulation of the mesenchymal markers α-SMA, collagen?Ⅰ, vimentin and fibronectin. Our study provided evidence that QGHXR inhibits EMT in alcoholic liver fibrosis by regulating the transforming growth factor-β1/Smad signaling pathway and that QGHXR-mediated inhibition of EMT might be a promising approach to ameliorating alcoholic liver injury.
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| Publish Date |
2016-05-17 10:45 |
| Citation |
Wu T, Chen JM, Xiao TG, Shu XB, Xu HC, Yang LL, Xing LJ, Zheng PY, Ji G. Qinggan Huoxue Recipe suppresses epithelial-to-mesenchymal transition in alcoholic liver fibrosis through TGF-1/Smad signaling pathway. World J Gastroenterol 2016; 22(19): 4695-4706 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i19/4695.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i19.4695 |
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