Publication Name	World Journal of Gastroenterology
Manuscript ID	23770
Country

Received	2015-12-16 08:27
Peer-Review Started	2015-12-17 14:53
To Make the First Decision	2015-12-30 16:35
Return for Revision	2016-01-05 10:42
Revised	2016-01-12 03:26
Second Decision	2016-01-29 16:52
Accepted by Journal Editor-in-Chief	2016-01-29 19:03
Accepted by Executive Editor-in-Chief	2016-02-22 10:34
Articles in Press	2016-02-22 10:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-29 14:58
Publish the Manuscript Online	2016-03-14 08:44

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections
Manuscript Source	Invited Manuscript
All Author List	Lynne Vernice McFarland, Metehan Ozen, Ener Cagri Dinleyici and Shan Goh
Funding Agency and Grant Number
Corresponding Author	Lynne Vernice McFarland, PhD, Affiliate Associate Professor, Department of Medicinal Chemistry, School of Pharmacy, University of Washington, 1660 South Columbian Way, Puget Sound Health Care System, S-152 Seattle, WA 98108-1597, United States. lvmcfarl@u.washington.edu
Key Words	Antibiotics; Antibiotic-associated diarrhea; Clostridum difficile infections; Adults; Pediatrics; Diarrhea; Risk factors; Treatments; Prevention
Core Tip	Differences and similarities in clinical pre-sentation and response to treatments were noted in pediatric and adult patients with regards to antibiotic-associated diarrhea and Clostridum difficile infections. Pediatric patients typically become symptomatic more rapidly, but also recover quicker than adults. While antibiotics are the major risk factor for both children and adult patients, adults have a more complex risk factor profile. Children respond best to metronidazole, while adults respond better to vancomycin. More studies are needed to characterize the disease process in antibiotic-associated diarrhea and treatment guidelines for pediatric patients.
Publish Date	2016-03-14 08:44
Citation	McFarland LV, Ozen M, Dinleyici EC, Goh S. Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections. World J Gastroenterol 2016; 22(11): 3078-3104
URL	http://www.wjgnet.com/1007-9327/full/v22/i11/3078.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i11.3078

Full Article (PDF)	WJG-22-3078.pdf
Full Article (Word)	WJG-22-3078.doc
Manuscript File	23770-Review.docx
Answering Reviewers	23770-Answering reviewers.pdf
Audio Core Tip	23770-Audio core tip.WMA
Conflict-of-Interest Disclosure Form	23770-Conflict-of-interest statement.pdf
Copyright License Agreement	23770-Copyright assignment.pdf
Peer-review Report	23770-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23770-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23770-Scientific misconduct check.pdf
Scientific Editor Work List	23770-Scientific editor work list.pdf