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Articles Published Processes
4/19/2016 9:45:00 AM | Browse: 1162 | Download: 2184
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Received |
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2015-12-16 08:24 |
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Peer-Review Started |
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2015-12-17 14:58 |
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To Make the First Decision |
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2016-01-13 08:35 |
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Return for Revision |
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2016-01-15 16:27 |
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Revised |
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Second Decision |
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2016-03-11 09:36 |
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Accepted by Journal Editor-in-Chief |
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2016-03-14 13:05 |
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Accepted by Executive Editor-in-Chief |
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2016-03-18 17:25 |
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Articles in Press |
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2016-03-18 17:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-03-23 15:14 |
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Publish the Manuscript Online |
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2016-04-19 09:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Aditya Ambade, Abhishek Satishchandran, Benedek Gyongyosi, Patrick Lowe and Gyongyi Szabo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH/NIAAA |
AA011576 |
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| Corresponding Author |
Gyongyi Szabo, MD, PhD, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605,
United States. gyongyi.szabo@umassmed.edu
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| Key Words |
alpha-fetoprotein; macrophage polarization; steatohepatitis; proliferating cell nuclear antigen; liver tumor |
| Core Tip |
Chronic alcohol consumption leads to broad spectrum of disorders from steatosis to steatohepatitis to cirrhosis and hepatocellular cancer (HCC). Currently there are no animal models of HCC that evaluate effect of alcoholic liver disease (ALD) on HCC acceleration. We describe a new 12-wk HCC model in adult mice that develops in livers with alcoholic hepatitis and defines ALD as co-factor in HCC. Our model involves sequential step-wise progression of ALD to HCC and highlights the role of alcohol as a tumor promoting agent. Importantly, our model shows inflammation, cellular regeneration, and fibrosis, all the features of human HCC pathogenesis.
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| Publish Date |
2016-04-19 09:42 |
| Citation |
Ambade A, Satishchandran A, Gyongyosi B, Lowe P, Szabo G. Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease. World J Gastroenterol 2016; 22(16): 4091-4108 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i16/4091.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i16.4091 |
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