Publication Name	World Journal of Gastroenterology
Manuscript ID	23832
Country	United Kingdom

Received	2015-12-19 15:12
Peer-Review Started	2015-12-22 09:40
To Make the First Decision	2016-01-13 08:49
Return for Revision	2016-01-13 10:05
Revised	2016-01-30 03:07
Second Decision	2016-02-19 09:23
Accepted by Journal Editor-in-Chief	2016-02-20 06:05
Accepted by Executive Editor-in-Chief	2016-03-02 08:14
Articles in Press	2016-03-02 08:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-17 14:54
Publish the Manuscript Online	2016-03-23 16:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Systematic Reviews
Article Title	Glucose metabolic phenotype of pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Anthony KC Chan, Jason IE Bruce and Ajith K Siriwardena
Funding Agency and Grant Number
Corresponding Author	Ajith K Siriwardena, MD, FRCS, Professor, Hepato-Pancreato-Biliary Surgery Unit, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom. ajith.siriwardena@cmft.nhs.uk
Key Words	Metabolism; Pancreatic cancer; Warburg effect; Metabolic inhibitor; Glycolysis; Krebs cycle
Core Tip	Our systematic review constructs a global “metabolic phenotype” of pancreatic ductal adeno-carcinoma (PDAC) reflecting tumour-related metabolic enzyme expression. We show that the Warburg effect is consistently demonstrated, with the over-expression of glycolytic enzymes and lacate dehydrogenase to facilitate rapid adenosine-triphosphate (ATP) production from glycolysis. We also show that the Warburg effect on mitochrondial oxidative phosphorylation in PDAC is more varied and not solely focused on ATP production, but also to stimulate other anabolic pathways for the purposes of tumourigencity. The metabolic phenotype provides an overview essential to elucidating the pathological changes that occur in PDAC.
Publish Date	2016-03-23 16:22
Citation	Chan AKC, Bruce JIE, Siriwardena AK. Glucose metabolic phenotype of pancreatic cancer. World J Gastroenterol 2016; 22(12): 3471-3485
URL	http://www.wjgnet.com/1007-9327/full/v22/i12/3471.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i12.3471

Full Article (PDF)	WJG-22-3471.pdf
Full Article (Word)	WJG-22-3471.doc
Manuscript File	23832-Review.docx
Answering Reviewers	23832-Answering reviewers.pdf
Audio Core Tip	23832-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	23832-Conflict-of-interest statement.pdf
Copyright License Agreement	23832-Copyright assignment.pdf
Peer-review Report	23832-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23832-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23832-Scientific misconduct check.pdf
Scientific Editor Work List	23832-Scientific editor work list.pdf