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3/23/2016 4:26:00 PM | Browse: 619 | Download: 818
Publication Name World Journal of Gastroenterology
Manuscript ID 23832
Country/Territory United Kingdom
2015-12-19 15:12
Peer-Review Started
2015-12-22 09:40
To Make the First Decision
2016-01-13 08:49
Return for Revision
2016-01-13 10:05
2016-01-30 03:07
Second Decision
2016-02-19 09:23
Accepted by Journal Editor-in-Chief
2016-02-20 06:05
Accepted by Company Editor-in-Chief
2016-03-02 08:14
Articles in Press
2016-03-02 08:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-03-17 14:54
Publish the Manuscript Online
2016-03-23 16:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Systematic Reviews
Article Title Glucose metabolic phenotype of pancreatic cancer
Manuscript Source Invited Manuscript
All Author List Anthony KC Chan, Jason IE Bruce and Ajith K Siriwardena
Funding Agency and Grant Number
Corresponding author Ajith K Siriwardena, MD, FRCS, Professor, Hepato-Pancreato-Biliary Surgery Unit, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom. ajith.siriwardena@cmft.nhs.uk
Keywords Metabolism; Pancreatic cancer; Warburg effect; Metabolic inhibitor; Glycolysis; Krebs cycle
Core Tip Our systematic review constructs a global “metabolic phenotype” of pancreatic ductal adeno-carcinoma (PDAC) reflecting tumour-related metabolic enzyme expression. We show that the Warburg effect is consistently demonstrated, with the over-expression of glycolytic enzymes and lacate dehydrogenase to facilitate rapid adenosine-triphosphate (ATP) production from glycolysis. We also show that the Warburg effect on mitochrondial oxidative phosphorylation in PDAC is more varied and not solely focused on ATP production, but also to stimulate other anabolic pathways for the purposes of tumourigencity. The metabolic phenotype provides an overview essential to elucidating the pathological changes that occur in PDAC.
Publish Date 2016-03-23 16:22
Citation Chan AKC, Bruce JIE, Siriwardena AK. Glucose metabolic phenotype of pancreatic cancer. World J Gastroenterol 2016; 22(12): 3471-3485
Url http://www.wjgnet.com/1007-9327/full/v22/i12/3471.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i12.3471
Full Article (PDF) WJG-22-3471.pdf
Full Article (Word) WJG-22-3471.doc
Manuscript File 23832-Review.docx
Answering Reviewers 23832-Answering reviewers.pdf
Audio Core Tip 23832-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 23832-Conflict-of-interest statement.pdf
Copyright License Agreement 23832-Copyright assignment.pdf
Data Sharing Statement 23832-Data sharing statement.pdf
Peer-review Report 23832-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 23832-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 23832-Scientific misconduct check.pdf
Scientific Editor Work List 23832-Scientific editor work list.pdf