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Articles Published Processes
4/29/2016 4:50:00 PM | Browse: 1005 | Download: 1703
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Received |
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2015-12-30 17:30 |
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Peer-Review Started |
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2015-12-31 08:42 |
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To Make the First Decision |
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2016-01-28 15:05 |
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Return for Revision |
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2016-01-29 18:36 |
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Revised |
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2016-02-22 11:41 |
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Second Decision |
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2016-03-04 18:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-03-14 09:45 |
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Articles in Press |
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2016-03-14 09:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-03-19 09:49 |
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Typeset the Manuscript |
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2016-03-24 15:31 |
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Publish the Manuscript Online |
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2016-04-29 16:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Inhibitory effect of miR-125b on hepatitis C virus core protein-induced TLR2/MyD88 signaling in THP-1 cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cheng Peng, Hua Wang, Wen-Jing Zhang, Sheng-Hua Jie, Qiao-Xia Tong, Meng-Ji Lu and Dong-Liang Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81202321 |
| National Natural Science Foundation of China |
81461130019 |
| Transregio-SFB (TRR) of the Deutsche Forschungsgemeinschaft (DFG) |
TRR60 |
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| Corresponding Author |
Dong-Liang Yang, MD, PhD, DSc. (Med), Professor, Chief, Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. dlyang@hust.edu.cn
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| Key Words |
miR-125b; Hepatitis virus C; Toll like receptor 2; Monocytes; Innate immunity |
| Core Tip |
Increasingly many studies have shown that microRNAs are critical regulators of the innate immune response. Many anti-pathogen pathways, including the pattern recognition Toll-like receptor (TLR)-mediated signaling pathway, are known to be regulated by a network of microRNAs. Here we investigated the possible role of miR-125b in regulating the monocyte immune responses induced by HCV core protein through TLR2/MyD88 signaling. Our findings indicated that miR-125b may function as a negative regulator of HCV-induced cellular events, which may provide insight into the role of miR-125b in the innate immune responses of monocytes to HCV.
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| Publish Date |
2016-04-29 16:50 |
| Citation |
Peng C, Wang H, Zhang WJ, Jie SH, Tong QX, Lu MJ, Yang DL. Inhibitory effect of miR-125b on hepatitis C virus core protein-induced TLR2/MyD88 signaling in THP-1 cells. World J Gastroenterol 2016; 22(17): 4354-4361 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i17/4354.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i17.4354 |
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