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Articles Published Processes
3/29/2016 3:29:00 PM | Browse: 1384 | Download: 2620
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Received |
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2015-12-22 09:29 |
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Peer-Review Started |
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2015-12-22 15:25 |
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To Make the First Decision |
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2016-01-13 08:49 |
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Return for Revision |
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2016-01-13 10:27 |
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Revised |
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2016-01-28 00:36 |
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Second Decision |
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2016-02-19 09:23 |
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Accepted by Journal Editor-in-Chief |
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2016-02-20 07:09 |
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Accepted by Executive Editor-in-Chief |
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2016-03-02 08:15 |
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Articles in Press |
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2016-03-02 08:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-03-16 17:50 |
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Publish the Manuscript Online |
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2016-03-29 15:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Andrea Sanchez-Pareja, Sophie Clément, Marion Peyrou, Laurent Spahr, Francesco Negro, Laura Rubbia-Brandt and Michelangelo Foti |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Swiss National Science Foundation |
314730-146991 |
| Swiss National Science Foundation |
310030-152618 |
| Swiss National Science Foundation |
CRSII3-160717 |
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| Corresponding Author |
Michelangelo Foti, Professor, Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, Centre Médical Universitaire, 1 rue Michel-Servet, 1211 Geneva, Switzerland. michelangelo.foti@unige.ch |
| Key Words |
Fibrosis; Phosphatase and tensin homolog; Steatosis; Non-alcoholic fatty liver disease; Nonalcoholic steatohepatitis; Alcoholic liver disease; Cirrhosis; Hepatocellular carcinoma |
| Core Tip |
Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) display similar histopathological features making difficult to discriminate between them apart from patient history. In this report, we assessed the phosphatase and tensin homolog (PTEN) expression level by immunohistochemistry and observed that while PTEN was downregulated in steatotic hepatocytes from patients with NAFLD, its expression remained unchanged in patients with ALD. We therefore propose that the evaluation of PTEN expression could be a useful tool for the differential diagnosis of NAFLD and ALD. |
| Publish Date |
2016-03-29 15:29 |
| Citation |
Sanchez-Pareja A, Clément S, Peyrou M, Spahr L, Negro F, Rubbia-Brandt L, Foti M. Phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease. World J Gastroenterol 2016; 22(14): 3735-3745 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i14/3735.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i14.3735 |
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