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3/29/2016 3:29:00 PM | Browse: 664 | Download: 1086
Publication Name World Journal of Gastroenterology
Manuscript ID 23874
Country/Territory Switzerland
Received
2015-12-22 09:29
Peer-Review Started
2015-12-22 15:25
To Make the First Decision
2016-01-13 08:49
Return for Revision
2016-01-13 10:27
Revised
2016-01-28 00:36
Second Decision
2016-02-19 09:23
Accepted by Journal Editor-in-Chief
2016-02-20 07:09
Accepted by Company Editor-in-Chief
2016-03-02 08:15
Articles in Press
2016-03-02 08:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-03-16 17:50
Publish the Manuscript Online
2016-03-29 15:29
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease
Manuscript Source Invited Manuscript
All Author List Andrea Sanchez-Pareja, Sophie Clément, Marion Peyrou, Laurent Spahr, Francesco Negro, Laura Rubbia-Brandt and Michelangelo Foti
Funding Agency and Grant Number
Funding Agency Grant Number
Swiss National Science Foundation 314730-146991
Swiss National Science Foundation 310030-152618
Swiss National Science Foundation CRSII3-160717
Corresponding author Michelangelo Foti, Professor, Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, Centre Médical Universitaire, 1 rue Michel-Servet, 1211 Geneva, Switzerland. michelangelo.foti@unige.ch
Keywords Fibrosis; Phosphatase and tensin homolog; Steatosis; Non-alcoholic fatty liver disease; Nonalcoholic steatohepatitis; Alcoholic liver disease; Cirrhosis; Hepatocellular carcinoma
Core Tip Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) display similar histopathological features making difficult to discriminate between them apart from patient history. In this report, we assessed the phosphatase and tensin homolog (PTEN) expression level by immunohistochemistry and observed that while PTEN was downregulated in steatotic hepatocytes from patients with NAFLD, its expression remained unchanged in patients with ALD. We therefore propose that the evaluation of PTEN expression could be a useful tool for the differential diagnosis of NAFLD and ALD.
Publish Date 2016-03-29 15:29
Citation Sanchez-Pareja A, Clément S, Peyrou M, Spahr L, Negro F, Rubbia-Brandt L, Foti M. Phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease. World J Gastroenterol 2016; 22(14): 3735-3745
Url http://www.wjgnet.com/1007-9327/full/v22/i14/3735.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i14.3735
Full Article (PDF) WJG-22-3735.pdf
Full Article (Word) WJG-22-3735.doc
Manuscript File 23874-Review.docx
Answering Reviewers 23874-Answering reviewers.pdf
Audio Core Tip 23874-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 23874-Conflict-of-interest statement.pdf
Copyright License Agreement 23874-Copyright assignment.pdf
Data Sharing Statement 23874-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 23874-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 23874-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 23874-Institutional review board statement.pdf
Peer-review Report 23874-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 23874-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 23874-Scientific misconduct check.pdf
Scientific Editor Work List 23874-Scientific editor work list.pdf