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Articles Published Processes
4/19/2016 9:45:00 AM | Browse: 1079 | Download: 1689
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Received |
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2015-12-26 15:20 |
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Peer-Review Started |
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2015-12-28 10:08 |
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To Make the First Decision |
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2015-12-30 16:35 |
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Return for Revision |
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2016-01-05 11:18 |
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Revised |
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2016-01-17 11:20 |
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Second Decision |
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2016-01-29 16:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-02-22 10:39 |
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Articles in Press |
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2016-02-22 10:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-03-22 14:12 |
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Typeset the Manuscript |
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2016-04-05 12:30 |
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Publish the Manuscript Online |
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2016-04-19 09:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Hu Chen, Yan-Yan Wang, Wei-Biao Lv, Yu Gan, Wei Chang, Na-Na Tian, Xiao-Hui Huang, Li Liu, Xin-Fa Yu and Si-Dong Chen |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Si-Dong Chen, Professor, Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou 510515, Guangdong Province,
China. chensidong1@126.com
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| Key Words |
Hepatocellular carcinoma; Kinesin family member 1B; Environmental factors; Alcohol drinking; Gene-environment interaction |
| Core Tip |
KIF1B has been proposed as a promising susceptibility gene for hepatocellular carcinoma (HCC) by a recent genome-wide association study (GWAS) in Chinese populations. However, the most significant variant (rs17401966) in this GWAS yielded inconsistent results in subsequent replication studies. In this work, we evaluated the role of rs17401966 in genetic susceptibility to HCC and gene-environment interactions. Our study demonstrates that the gene-environment interaction between the KIF1B rs17401966 variant and drinking alcohol significantly contributed to the development of HCC in the Chinese population.
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| Publish Date |
2016-04-19 09:42 |
| Citation |
Chen JH, Wang YY, Lv WB, Gan Y, Chang W, Tian NN, Huang XH, Liu L, Yu XF, Chen SD. Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort. World J Gastroenterol 2016; 22(16): 4183-4190 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i16/4183.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i16.4183 |
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