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Articles Published Processes
5/4/2016 10:08:00 AM | Browse: 1144 | Download: 2205
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Received |
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2015-12-26 15:09 |
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Peer-Review Started |
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2015-12-28 10:49 |
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To Make the First Decision |
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2016-01-13 08:36 |
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Return for Revision |
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2016-01-18 20:00 |
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Revised |
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2016-02-03 10:27 |
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Second Decision |
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2016-02-25 18:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-03-02 08:01 |
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Articles in Press |
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2016-03-02 08:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-03-30 16:29 |
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Typeset the Manuscript |
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2016-04-21 17:15 |
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Publish the Manuscript Online |
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2016-05-04 10:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Peer-review started: February 25, 2016 |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Elevated serum interleukin-38 level at baseline predicts virological response in telbivudine-treated patients with chronic hepatitis B
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hong-Juan Wang, Yan-Fang Jiang, Xin-Rui Wang, Man-Li Zhang and Pu-Jun Gao |
| Funding Agency and Grant Number |
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| Corresponding Author |
Pu-Jun Gao, MD, PhD, Department of Hepatology, First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, Jilin Province, China. pujun-gao@163.com |
| Key Words |
Alanine aminotransferase; Aspartate amino¬transferase; Interleukin-6; Interleukin-12; Interleukin-38; Chronic hepatitis B; Primary non-response; Virological response |
| Core Tip |
This is the first study detailing kinetic changes in serum interleukin-38 (IL-38) levels during chronic hepatitis B (CHB). Higher pretreatment serum IL-38 levels are associated with a greater probability of virological response to telbivudine treatment. Elevated levels of serum IL-38 in untreated patients with CHB reflect ongoing liver injury, which is an indirect indicator of vigorous endogenous clearance of hepatitis B virus infection. Our findings suggest that clear signs of viral clearance at baseline may predict a favorable response to treatment of CHB using nucleoside analogs. |
| Publish Date |
2016-05-04 10:08 |
| Citation |
Wang HJ, Jiang YF, Wang XR, Zhang ML, Gao PJ. Elevated serum interleukin-38 level at baseline predicts virological response in telbivudine-treated patients with chronic hepatitis B. World J Gastroenterol 2016; 22(18): 4529-4537 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i18/4529.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i18.4529 |
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