Publication Name	World Journal of Gastroenterology
Manuscript ID	23935
Country	Mexico

Received	2015-12-26 15:04
Peer-Review Started	2015-12-28 11:10
To Make the First Decision	2016-01-28 14:22
Return for Revision	2016-01-30 11:04
Revised	2016-02-14 14:19
Second Decision	2016-02-25 18:39
Accepted by Journal Editor-in-Chief	2016-02-28 16:01
Accepted by Executive Editor-in-Chief	2016-03-02 08:01
Articles in Press	2016-03-02 08:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-17 15:55
Publish the Manuscript Online	2016-03-29 15:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells
Manuscript Source	Invited Manuscript
All Author List	Sonia Amelia Lozano-Sepulveda, Eduardo Bautista-Osorio, Jose Angel Merino-Mascorro, Marta Varela-Rey, Linda Elsa Muñoz-Espinosa, Paula Cordero-Perez, María Luz Martinez-Chantar and Ana Maria Rivas-Estilla
Funding Agency and Grant Number	Funding Agency Grant Number CONACYT-Mexico CB2010-01-155082
Corresponding Author	Dr. Ana Maria Rivas-Estilla, Department of Biochemistry and Molecular Medicine, School of Medicine, Autonomous University of Nuevo Leon, Francisco I. Madero y Ave. Gonzalitos s/n Col. Mitras Centro, Monterrey, Nuevo Leon 64460, Mexico. amrivas1@yahoo.ca
Key Words	Hepatitis C virus; S-adenosyl-L-methionine; Superoxide dismutase 1; Superoxide dismutase 2; Replication; Hepatitis C virus-RNA; NS5A; Oxidative stress; Antioxidants; Viral proteins; Reactive oxygen species; Pyrrolidine dithiocarbamate
Core Tip	S-adenosyl-L-methionine (SAM) downregulates hepatitis C virus (HCV) expression by unknown mechanisms. We evaluated the effects of SAM on viral expression using an HCV subgenomic replicon cell culture system. We observed that SAM induces a synergic antiviral effect with standard interferon (IFN) treatment independently of IFN signaling pathways; it does not modify viral RNA stability, but it needs cellular translation machinery in order to decrease HCV expression. In addition, results demonstrated that a likely mechanism(s) by which SAM decreases HCV expression could involve modulating antioxidant enzyme systems, restoring biosynthesis of glutathione and switching methionine adenosyltransferase 1 (MAT1)/MAT2 turnover in HCV expressing cells.
Publish Date	2016-03-29 15:29
Citation	Lozano-Sepulveda SA, Bautista-Osorio E, Merino-Mascorro JA, Varela-Rey M, Muñoz-Espinosa LE, Cordero-Perez P, Martinez-Chantar ML, Rivas-Estilla AM. S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells. World J Gastroenterol 2016; 22(14): 3746-3757
URL	http://www.wjgnet.com/1007-9327/full/v22/i14/3746.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i14.3746

Full Article (PDF)	WJG-22-3746.pdf
Full Article (Word)	WJG-22-3746.doc
Manuscript File	23935-Review.docx
Answering Reviewers	23935-Answering reviewers.pdf
Audio Core Tip	23935-Audio core tip.mp3
Biostatistics Review Certificate	23935-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	23935-Conflict-of-interest statement.pdf
Copyright License Agreement	23935-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	23935-Grant application form.pdf
Institutional Review Board Approval Form or Document	23935-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	23935-Language certificate.pdf
Peer-review Report	23935-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23935-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23935-Scientific misconduct check.pdf
Scientific Editor Work List	23935-Scientific editor work list.pdf