Publication Name	World Journal of Hepatology
Manuscript ID	23985
Country	United States

Received	2015-12-29 09:25
Peer-Review Started	2016-01-01 15:11
To Make the First Decision	2016-02-02 08:45
Return for Revision	2016-02-02 09:27
Revised	2016-02-18 00:00
Second Decision	2016-02-29 09:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-03-14 12:01
Articles in Press	2016-03-14 12:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-05-07 16:26
Publish the Manuscript Online	2016-05-12 10:37

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Direct acting antiviral therapy is curative for chronic hepatitis C/autoimmune hepatitis overlap syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Farhad Sahebjam, Cristina H Hajdu, Esther Nortey and Samuel H Sigal
Funding Agency and Grant Number
Corresponding Author	Samuel H Sigal, MD, Division of Gastro­enterology and Liver Diseases, Montefiore Medical Center and Albert Einstein College of Medicine, 111 210th Street, Rosenthal 2, Bronx, NY 10467, United States. ssigal@montefiore.org
Key Words	Hepatitis C; Autoimmune hepatitis; Overlap syndrome; Direct acting antiviral therapy
Core Tip	Autoimmune phenomena are common in patients with chronic hepatitis C, and occasionally patients with chronic hepatitis C have concomitant features of autoimmune hepatitis (AIH). Management of these patients has until recently been problematic due to the adverse effects of interferon on autoimmune processes and immunosuppression on viral replication. In this report we describe 3 patients with chronic hepa-titis C/AIH overlap syndrome who responded rapidly to direct acting anti-viral therapy with prompt normalization of liver tests and progressive decrease in the serologic markers of AIH. The resolution of the autoimmune process supports a direct viral role in its pathophysiology.
Publish Date	2016-05-12 10:37
Citation	Sahebjam F, Hajdu CH, Nortey E, Sigal SH. Direct acting antiviral therapy is curative for chronic hepatitis C/autoimmune hepatitis overlap syndrome. World J Hepatol 2016; 8(14): 632-636
URL	http://www.wjgnet.com/1948-5182/full/v8/i14/632.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i14.632

Full Article (PDF)	WJH-8-632.pdf
Full Article (Word)	WJH-8-632.doc
Manuscript File	23985-Review.docx
Answering Reviewers	23985-Answering reviewers.pdf
Audio Core Tip	23985-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	23985-Conflict-of-interest statement.pdf
Copyright License Agreement	23985-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20151229014215.docx
Institutional Review Board Approval Form or Document	23985-Institutional review board statement.pdf
Peer-review Report	23985-Peer-review(s).pdf
Scientific Misconduct Check	23985-Scientific misconduct check.pdf
Scientific Editor Work List	23985-Scientific editor work list.pdf