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6/22/2016 6:16:00 PM | Browse: 836 | Download: 1410
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Received |
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2016-01-03 17:35 |
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Peer-Review Started |
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2016-01-03 18:11 |
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To Make the First Decision |
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2016-02-02 08:47 |
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Return for Revision |
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2016-02-02 09:51 |
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Revised |
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2016-02-15 19:09 |
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Second Decision |
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2016-03-14 08:47 |
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Accepted by Journal Editor-in-Chief |
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2016-03-14 19:33 |
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Accepted by Company Editor-in-Chief |
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2016-03-18 16:02 |
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Articles in Press |
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2016-03-18 16:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-05-19 17:40 |
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Publish the Manuscript Online |
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2016-06-22 16:18 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Retrospective Study |
| Article Title |
Higher plasma bilirubin predicts veno-occlusive disease in early childhood undergoing hematopoietic stem cell transplantation with cyclosporine
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kwi Suk Kim, Aree Moon, Hyoung Jin Kang, Hee Young Shin, Young Hee Choi, Hyang Sook Kim and Sang Geon Kim |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Education and Research Encouragement Fund of Seoul National University Hospital |
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| Corresponding Author |
Sang Geon Kim, PhD, Professor, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 101 Daehak-ro Jongno-gu, Seoul 03080, South Korea. sgk@snu.ac.kr
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| Key Words |
Hematopoietic stem cell transplantation; Veno-occlusive disease; Cyclosporine; Adverse drug reaction; Total bilirubin |
| Core Tip |
This study analyzed the association between plasma bilirubin and veno-occlusive disease (VOD) in childhood undergoing hematopoietic stem cell trans-plantation (HSCT) during cyclosporine therapy. Here, we report that age of 8 or under may be a risk factor for VOD in CsA-treated patients who underwent HSCT with differential clearance of CsA. Another finding is that a criterion of 1.4 mg/dL of plasma maximal total bilirubin level or higher content alone closely represents the incidence of VOD in early childhood patients with HSCT in CsA therapy. Information shown in this study would be of great help to understand VOD occurring during CsA medication and to find optimal pharmacotherapy in HSCT patients.
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| Publish Date |
2016-06-22 16:18 |
| Citation |
Kim KS, Moon A, Kang HJ, Shin HY, Choi YH, Kim HS, Kim SG. Higher plasma bilirubin predicts veno-occlusive disease in early childhood undergoing hematopoietic stem cell transplantation with cyclosporine. World J Transplant 2016; 6(2): 403-410 |
| URL |
http://www.wjgnet.com/2220-3230/full/v6/i2/403.htm |
| DOI |
http://dx.doi.org/10.5500/wjt.v6.i2.403 |
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