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Articles Published Processes
5/19/2016 2:49:00 PM | Browse: 1041 | Download: 1634
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Received |
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2016-01-09 13:15 |
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Peer-Review Started |
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2016-01-09 21:28 |
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To Make the First Decision |
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2016-02-18 09:46 |
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Return for Revision |
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2016-02-18 14:48 |
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Revised |
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2016-02-29 10:53 |
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Second Decision |
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2016-03-11 09:34 |
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Accepted by Journal Editor-in-Chief |
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2016-03-13 08:03 |
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Accepted by Executive Editor-in-Chief |
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2016-03-18 17:39 |
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Articles in Press |
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2016-03-18 17:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-03-28 08:19 |
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Typeset the Manuscript |
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2016-03-31 11:03 |
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Publish the Manuscript Online |
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2016-05-19 14:49 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
miR-29a up-regulation in AR42J cells contributes to apoptosis via targeting TNFRSF1A gene
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qiang Fu, Tao Qin, Lin Chen, Chuan-Jiang Liu, Xu Zhang, Yu-Zhu Wang, Ming-Xing Hu, Hao-Yuan Chu and Hong-Wei Zhang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Hong-Wei Zhang, MD, PhD, Professor, Chief, Department of Hepatobiliary Pancreatic Surgery, People’s Hospital of Zhengzhou University, School of Medicine, Zhengzhou University, No. 7 Weiwu Road, Zhengzhou 450003, Henan Province, China. hwzhang666@126.com
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| Key Words |
Acute edematous pancreatitis; miR-29a; Apoptosis; AR42J; Target gene; TNFRSF1A |
| Core Tip |
Apoptosis is a self-protection mechanism in acute pancreatitis. miRNAs are short non-coding RNAs and play important roles in regulating gene expression in multiple cellular processes, such as apoptosis. Here, our group studied the role of miR-29a in pancreatic acinar cell apoptosis. The pancreatic acinar cells showed a tendency to apoptosis when the expression of miR-29a elevated, while the apoptosis rate exhibited the opposite trend by down-regulating the expression of miR-29a. Moreover, we found TNFRSF1A, which encode TNFR1 protein, was a target gene of miR-29a. Our results demonstrated that miR-29a could promote the apoptosis of pancreatic acinar cells via up-regulating the expression of TNFRSF1A gene in acute pancreatitis.
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| Publish Date |
2016-05-19 14:49 |
| Citation |
Fu Q, Qin T, Chen L, Liu CJ, Zhang X, Wang YZ, Hu MX, Chu HY, Zhang HW. miR-29a up-regulation in AR42J cells contributes to apoptosis via targeting TNFRSF1A gene. World J Gastroenterol 2016; 22(20): 4881-4890 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i20/4881.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i20.4881 |
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