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Articles Published Processes
8/27/2014 6:41:00 PM | Browse: 1186 | Download: 1045
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Received |
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2013-02-20 09:03 |
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Peer-Review Started |
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2013-02-20 15:44 |
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To Make the First Decision |
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2013-03-11 15:09 |
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Return for Revision |
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2013-03-17 18:19 |
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Revised |
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2013-04-06 00:33 |
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Second Decision |
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2013-05-16 20:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2013-05-17 09:44 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2013-06-17 11:11 |
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Publish the Manuscript Online |
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2013-06-28 16:48 |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Peroxisome-proliferator-activated receptors regulate redox signaling in the cardiovascular system
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Teayoun Kim and Qinglin Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
1R01 HL085499 (to Yang Q) |
| National Institutes of Health |
1R01 HL084456 (to Kim T) |
| National Institutes of Health |
T32 HL007457 (to Kim T) |
| ADA Basic Science Award |
#7-12-BS-208 (to Yang Q) |
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| Corresponding Author |
Qinglin Yang, MD, PhD, Professor, Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Blvd., Webb 435, Birmingham, AL 35294-3360, United States. qyang@uab.edu |
| Key Words |
Peroxisome-proliferator-activated receptor; Redox; Cardiovascular disorders; Oxidative stress; Antioxidant |
| Core Tip |
Numerous studies have shown that peroxisome-proliferator-activated receptors (PPARs) ligands can modulate antioxidants via various mechanisms. Importantly, direct transcriptional regulation of antioxidant genes, such as thioredoxin-1, glutathione peroxidase 3, sestrin-1, catalase, superoxide dismutase (SOD)1, SOD2, and heme oxygenase, is established by identifying functional PPAR responsive element in promoter regions of the above genes. This review summarizes how these important antioxidant genes are regulated by each subtype of PPARs in response to oxidative stress in the cardiovascular system and how oxidative stress affects PPAR function, as well as the biological implications in the cardiovascular system. |
| Publish Date |
2013-06-28 16:48 |
| Citation |
Kim T, Yang Q. Peroxisome-proliferator-activated receptors regulate redox signaling in the cardiovascular system. World J Cardiol 2013; 5(6): 164-174 |
| URL |
http://www.wjgnet.com/1949-8462/full/v5/i6/164.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v5.i6.164 |
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