Publication Name	World Journal of Gastroenterology
Manuscript ID	2411
Country	Türkiye

Received	2013-02-20 09:09
Peer-Review Started	2013-02-20 15:51
To Make the First Decision	2013-03-18 15:31
Return for Revision	2013-03-19 11:14
Revised	2013-03-22 19:53
Second Decision	2013-06-03 11:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-06-04 08:18
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-09 15:33
Publish the Manuscript Online	2013-08-27 16:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Investigation of genome instability in patients with non-alcoholic steatohepatitis
Manuscript Source	Invited Manuscript
All Author List	Hatice Karaman, Ahmet Karaman, Hamiyet Donmez-Altuntas, Nazmiye Bitgen, Zuhal Hamurcu, Arzu Oguz and Cigdem Karakukcu
Funding Agency and Grant Number
Corresponding Author	Hatice Karaman, MD, Department of Pathology, Kayseri Education and Research Hospital, Alpaslan Mah. Emrah Cad. Beyoğlu Apt. 21/3 Melikgazi, 38030 Kayseri, Turkey. htckaraman@yahoo.com
Key Words	Non-alcoholic steatohepatitis; Micronucleus; Nucleoplasmic bridges; Nuclear buds
Core Tip	We aimed to evaluate the micronucleus, nucleoplasmic bridges and nuclear buds in the mitogen-stimulated lymphocytes of patients with non-alcoholic steatohepatitis (NASH). Genomic instability may be a stage in the development of hepatic carcinogenesis. NASH is a major cause of so-called cryptogenic liver cirrhosis and can result in hepatocellular carcinoma (HCC). Our results support this suggestion; although none of the patients had liver cirrhosis in our study, there is high genomic instability in their mitogen-stimulated lymphocytes. Further prospective studies are needed to further clarify this topic, especially among patients with HCC, cirrhosis and NASH.
Publish Date	2013-08-27 16:46
Citation	Karaman H, Karaman A, Donmez-Altuntas H, Bitgen N, Hamurcu Z, Oguz A, Karakukcu C. Investigation of genome instability in patients with non-alcoholic steatohepatitis. World J Gastroenterol 2013; 19(32): 5295-5301
URL	http://www.wjgnet.com/1007-9327/full/v19/i32/5295.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i32.5295

Full Article (PDF)	WJG-19-5295.pdf
Manuscript File	2411-Review.doc
Answering Reviewers	2411-Answering reviewers.doc
Copyright License Agreement	2411-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2411-Language certificate.pdf
Peer-review Report	2411-Peer review(s).pdf
Scientific Editor Work List	2411-Scientific editor work list.doc