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Articles Published Processes
4/29/2016 4:50:00 PM | Browse: 1387 | Download: 2248
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Received |
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2016-01-10 16:57 |
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Peer-Review Started |
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2016-01-10 18:45 |
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To Make the First Decision |
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2016-01-28 14:46 |
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Return for Revision |
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2016-01-28 15:17 |
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Revised |
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2016-02-10 16:30 |
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Second Decision |
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2016-02-22 13:30 |
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Accepted by Journal Editor-in-Chief |
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2016-02-22 15:05 |
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Accepted by Executive Editor-in-Chief |
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2016-03-02 09:31 |
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Articles in Press |
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2016-03-02 09:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-03-17 14:22 |
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Publish the Manuscript Online |
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2016-04-29 16:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Growth hormone abolishes the negative effects of everolimus on intestinal wound healing
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Markus Alexander Küper, Sebastian Trütschel, Jürgen Weinreich, Alfred Königsrainer and Stefan Beckert |
| Funding Agency and Grant Number |
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| Corresponding Author |
Markus Alexander Küper, MD, BG Trauma Center, University of Tübingen, Schnarrenbergstraße 95, D-72076 Tübingen, Germany. mkueper@hotmail.com
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| Key Words |
Wound healing; Everolimus; Human growth hormone; Immunosuppression; mTOR-inhibitor; Growth hormone; Anastomotic healing |
| Core Tip |
Patients undergoing transplantation are set onto immunosuppressive medication afterwards. One agent is everolimus out of the group of the mTOR-inhibitors. Everolimus has been shown to inhibit healing of intestinal anastomoses by influencing the inflammatory phase of wound healing. Human growth hormone (hGH) has been shown to improve wound healing by increasing the amount of collagen in the wound. In this animal study we could demonstrate for the first time that a combined perioperative treat-ment with everolimus and hGH results in improved intestinal wound healing compared with everolimus alone. These results might be a step towards safer immunosuppression in transplanted patients.
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| Publish Date |
2016-04-29 16:50 |
| Citation |
Küper MA, Trütschel S, Weinreich J, Königsrainer A, Beckert S. Growth hormone abolishes the negative effects of everolimus on intestinal wound healing. World J Gastroenterol 2016; 22(17): 4321-4329 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i17/4321.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i17.4321 |
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