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4/29/2016 4:50:00 PM | Browse: 1238 | Download: 1797
Publication Name World Journal of Gastroenterology
Manuscript ID 24141
Country/Territory Germany
Received
2016-01-10 16:57
Peer-Review Started
2016-01-10 18:45
To Make the First Decision
2016-01-28 14:46
Return for Revision
2016-01-28 15:17
Revised
2016-02-10 16:30
Second Decision
2016-02-22 13:30
Accepted by Journal Editor-in-Chief
2016-02-22 15:05
Accepted by Company Editor-in-Chief
2016-03-02 09:31
Articles in Press
2016-03-02 09:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-03-17 14:22
Publish the Manuscript Online
2016-04-29 16:50
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Basic Study
Article Title Growth hormone abolishes the negative effects of everolimus on intestinal wound healing
Manuscript Source Invited Manuscript
All Author List Markus Alexander Küper, Sebastian Trütschel, Jürgen Weinreich, Alfred Königsrainer and Stefan Beckert
Funding Agency and Grant Number
Corresponding Author Markus Alexander Küper, MD, BG Trauma Center, University of Tübingen, Schnarrenbergstraße 95, D-72076 Tübingen, Germany. mkueper@hotmail.com
Key Words Wound healing; Everolimus; Human growth hormone; Immunosuppression; mTOR-inhibitor; Growth hormone; Anastomotic healing
Core Tip Patients undergoing transplantation are set onto immunosuppressive medication afterwards. One agent is everolimus out of the group of the mTOR-inhibitors. Everolimus has been shown to inhibit healing of intestinal anastomoses by influencing the inflammatory phase of wound healing. Human growth hormone (hGH) has been shown to improve wound healing by increasing the amount of collagen in the wound. In this animal study we could demonstrate for the first time that a combined perioperative treat-ment with everolimus and hGH results in improved intestinal wound healing compared with everolimus alone. These results might be a step towards safer immunosuppression in transplanted patients.
Publish Date 2016-04-29 16:50
Citation Küper MA, Trütschel S, Weinreich J, Königsrainer A, Beckert S. Growth hormone abolishes the negative effects of everolimus on intestinal wound healing. World J Gastroenterol 2016; 22(17): 4321-4329
URL http://www.wjgnet.com/1007-9327/full/v22/i17/4321.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i17.4321
Full Article (PDF) WJG-22-4321.pdf
Full Article (Word) WJG-22-4321.doc
Manuscript File 24141-Review.doc
Answering Reviewers 24141-Answering reviewers.pdf
Audio Core Tip 24141-Audio core tip.mp3
Biostatistics Review Certificate 24141-Biostatistics Statement.pdf
Conflict-of-Interest Disclosure Form 24141-Conflict-of-interest statement.pdf
Copyright License Agreement 24141-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 24141-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 24141-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 24141-Language certificate.pdf
Peer-review Report 24141-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 24141-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 24141-Scientific misconduct check.pdf
Scientific Editor Work List 24141-Scientific editor work list.pdf