Publication Name	World Journal of Psychiatry
Manuscript ID	24142
Country	Germany

Received	2016-01-11 17:47
Peer-Review Started
To Make the First Decision
Return for Revision
Revised
Second Decision	2016-02-17 13:58
Accepted by Journal Editor-in-Chief	2016-02-18 07:10
Accepted by Executive Editor-in-Chief	2016-02-24 15:10
Articles in Press	2016-02-24 15:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-04 10:09
Publish the Manuscript Online	2016-03-16 12:23

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Psychiatry
Manuscript Type	Review
Article Title	Systems psychopharmacology: A network approach to developing novel therapies
Manuscript Source	Invited Manuscript
All Author List	Peter J Gebicke-Haerter
Funding Agency and Grant Number
Corresponding Author	Dr. Peter J Gebicke-Haerter, Professor of Pharmacology and Toxicology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, 68159 Mannheim, Germany. peter.gebicke@zi-mannheim.de
Key Words	Polypharmacology; Drug-target networks; Network topology; Disease networks; Genome-wide association studies; Epigenetics; Schizophrenia; Herbal extracts
Core Tip	Pharmacotherapies of mental disorders have to take into account their multifactorial origins. Therefore, combinatorial drug therapies have to be devised targeting multiple molecules in disease networks. Mathematical approaches can aid in learning more about molecular interactions in disease networks and, by in silico simulations, discover dynamic changes in network properties. Targeting important nodes by drugs should be avoided to preserve network integrities. Efforts to find efficient combinations of drugs could be supported by more research into compounds contained in herbal extracts.
Publish Date	2016-03-16 12:23
Citation	Gebicke-Haerter PJ. Systems psychopharmacology: A network approach to developing novel therapies. World J Psychiatr 2016; 6(1): 66-83
URL	http://www.wjgnet.com/2220-3206/full/v6/i1/66.htm
DOI	http://dx.doi.org/10.5498/wjp.v6.i1.66

Full Article (PDF)	WJP-6-66.pdf
Full Article (Word)	WJP-6-66.doc
Manuscript File	24142-Review.doc
Answering Reviewers	24142-Answering reviewers.pdf
Audio Core Tip	24142-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	24142-Conflict-of-interest statement.pdf
Copyright License Agreement	24142-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	24142-Language certificate.pdf
Supplementary Material	Supplementary_Material_20160109050335.ppt
Peer-review Report	24142-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	24142-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	24142-Scientific misconduct check.pdf
Scientific Editor Work List	24142-Scientific editor work list.pdf