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Articles Published Processes
9/15/2014 4:47:00 PM | Browse: 1433 | Download: 1239
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Received |
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2013-02-20 09:51 |
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Peer-Review Started |
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2013-02-20 16:46 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2013-03-19 11:39 |
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Revised |
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2013-05-15 00:22 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2013-06-18 10:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2013-06-19 00:20 |
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Articles in Press |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2013-07-03 11:10 |
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Publish the Manuscript Online |
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2013-07-18 17:49 |
| Category |
Respiratory System |
| Manuscript Type |
Autobiography |
| Article Title |
High-frequency electrical stimulation of cervical vagi reduces airway response to methacholine
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jianguo Zhuang, Daniel Bailet, Robert Curtis and Fadi Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Heart, Lung, and Blood Institute, Bethesda, MD |
RO1 HL107462 |
| NeuroStimulation Techologies, Inc. Albuquerque, NM |
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| Corresponding Author |
Dr. Fadi Xu, Lovelace Respiratory Research Institute, Pathophysiology Program, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, United States. fxu@lrri.org |
| Key Words |
Bronchodilation; Acetylcholine; Airway hyperreactivity; Ovalbumin; Asthma |
| Core Tip |
In summary, our study revealed that vagal high-frequency electrical stimulation (HES) significantly suppressed the airway response to methacholine (MCh) more greatly in the ovalbumin- than saline-treated animals, while vagal low-frequency electrical stimulation always increased airway resistance. Importantly, the HES-evoked bronchodilation during MCh challenge is concomitant with the on-and-off electrical stimulation and with no effect on cardiovascular activity. These, along with the greatly blunted airway resistance response to MCh after bivagotomy, suggest that vagal HES may be a potentially useful approach in alleviating asthmatic bronchoconstriction (likely via reversible inhibition or blockade of the vagal nerve conduction). |
| Publish Date |
2013-07-18 17:49 |
| Citation |
Zhuang J, Bailet D, Curtis R, Xu F. High-frequency electrical stimulation of cervical vagi reduces airway response to methacholine. World J Respirol 2013; 3(2): 11-19
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| URL |
http://www.wjgnet.com/2218-6255/full/v3/i2/11.htm |
| DOI |
http://dx.doi.org/10.5320/wjr.v3.i2.11 |
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