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Articles Published Processes
5/19/2016 2:49:00 PM | Browse: 1029 | Download: 1776
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Received |
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2016-01-13 08:57 |
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Peer-Review Started |
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2016-01-15 09:26 |
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To Make the First Decision |
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2016-02-18 16:55 |
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Return for Revision |
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2016-02-20 15:36 |
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Revised |
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2016-03-05 17:47 |
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Second Decision |
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2016-03-31 10:23 |
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Accepted by Journal Editor-in-Chief |
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2016-04-01 20:37 |
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Accepted by Executive Editor-in-Chief |
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2016-04-07 15:53 |
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Articles in Press |
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2016-04-07 15:53 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-05-05 10:54 |
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Publish the Manuscript Online |
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2016-05-19 14:49 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Basic Study |
| Article Title |
Immunological changes in different patient populations with chronic hepatitis C virus infection
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Laszlo Szereday, Matyas Meggyes, Melinda Halasz, Julia Szekeres-Bartho, Alajos Par and Gabriella Par |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hungarian National Research Fund |
OTKA K81454 |
| Hungarian National Research Fund |
OTKA K104960 |
| Liver Research Foundation (Pécs), United European Gastroenterology Federation |
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| Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences |
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| Corresponding Author |
Laszlo Szereday, MD, PhD, Associate Professor of Microbiology, Department of Medical Microbiology and Immunology, University of Pecs, Clinical Centre, 7624 Pecs, Hungary. szereday.laszlo@pte.hu
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| Key Words |
Hepatitis C; Natural killer cell; NKG2D; Cytotoxicity; Cytokine |
| Core Tip |
The host immune response to hepatitis C virus (HCV) involves both innate and adaptive arms of the immune system. natural killer (NK) cells are key components of the innate antiviral immune response. To better characterize the immune defects underlying chronic viral persistence, we focus our analysis on killer inhibitory and activating receptor expression in patients with chronic HCV infection with elevated alanine aminotransferase (ALT) and also in patients with HCV carriers with persistently normal ALT. Decreased NKG2D and CD160 activating receptor expression and increased KIR2DL3 inhibitory receptor expression by NK and cytotoxic T cells in patients with chronic hepatitis C contributing to defective cellular immune functions. |
| Publish Date |
2016-05-19 14:49 |
| Citation |
Szereday L, Meggyes M, Halasz M, Szekeres-Bartho J, Par A, Par G. Immunological changes in different patient populations with chronic hepatitis C virus infection. World J Gastroenterol 2016; 22(20): 4848-4859 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i20/4848.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i20.4848 |
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