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Articles Published Processes
5/4/2016 10:08:00 AM | Browse: 1316 | Download: 2305
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Received |
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2016-01-14 09:11 |
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Peer-Review Started |
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2016-01-15 11:44 |
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To Make the First Decision |
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2016-03-21 08:33 |
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Return for Revision |
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2016-03-23 14:52 |
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Revised |
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2016-04-07 02:09 |
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Second Decision |
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2016-04-07 12:08 |
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Accepted by Journal Editor-in-Chief |
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2016-04-07 14:51 |
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Accepted by Executive Editor-in-Chief |
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2016-04-15 14:05 |
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Articles in Press |
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2016-04-15 14:06 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-04-19 10:41 |
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Publish the Manuscript Online |
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2016-05-04 10:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Peer-review started: February 25, 2016 |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Stefanos Bonovas, Gionata Fiorino, Theodore Lytras, Alberto Malesci and Silvio Danese |
| Funding Agency and Grant Number |
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| Corresponding Author |
Stefanos Bonovas, MD, MSc, PhD, Department of Gastroenterology, Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Milan, Italy. sbonovas@gmail.com |
| Key Words |
Calcium; Colorectal adenoma; Recurrence; Cancer chemoprevention; Colorectal cancer; Systematic review; Meta-analysis; Polyp |
| Core Tip |
To assess the efficacy of calcium supplementation in reducing the recurrence of colorectal adenomas, we conducted a systematic review and meta-analysis of randomized, placebo-controlled trials. We found a modest protective effect of calcium in prevention of adenomas (fixed-effects, RR = 0.89, 95%CI: 0.82-0.96; random-effects, RR = 0.87, 95%CI: 0.77-0.98; high quality of evidence). On the other hand, the association between calcium treatment and advanced (“high-risk”) colorectal adenomas was not statistically significant (fixed-effects, RR = 0.92, 95%CI: 0.75-1.13; random-effects, RR = 0.92, 95%CI: 0.71-1.18; moderate quality of evidence). Further targeted research is warranted. |
| Publish Date |
2016-05-04 10:08 |
| Citation |
Bonovas S, Fiorino G, Lytras T, Malesci A, Danese S. Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials. World J Gastroenterol 2016; 22(18): 4594-4603 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i18/4594.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i18.4594 |
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