Publication Name	World Journal of Gastroenterology
Manuscript ID	24250
Country	China

Received	2016-01-14 09:51
Peer-Review Started	2016-01-16 18:00
To Make the First Decision	2016-02-18 16:55
Return for Revision	2016-02-20 15:53
Revised	2016-02-27 23:31
Second Decision	2016-03-11 09:36
Accepted by Journal Editor-in-Chief	2016-03-11 23:53
Accepted by Executive Editor-in-Chief	2016-03-18 17:26
Articles in Press	2016-03-18 17:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-03-30 04:12
Typeset the Manuscript	2016-04-08 11:20
Publish the Manuscript Online	2016-05-04 10:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Peer-review started: February 25, 2016
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Expression of B7-H4 and hepatitis B virus X in hepatitis B virus-related hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Bo Hong, Yun Qian, Hong Zhang, Yi-Wen Sang, Lin-Fang Cheng, Qi Wang, Song Gao, Min Zheng and Hang-Ping Yao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81272679 National Natural Science Foundation of China 81470851 Zhejiang Provincial Natural Science Foundation of China LQ16H160005 Zhejiang Provincial Natural Science Foundation of China LY15H080002 Medical Science and Technology Project of Zhejiang Province 201337756 Educational Commission of Zhejiang Province of China Y201328079
Corresponding Author	Dr. Hang-Ping Yao, Professor, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. yaohangping@zju.edu.cn
Key Words	Hepatocellular carcinoma; Hepatitis B virus; Hepatitis B virus X; B7-H4; Immunohistochemistry
Core Tip	Hepatitis B virus (HBV) is a major public health problem, and HBV-related hepatocellular carcinoma (HBV-HCC) has an extremely poor prognosis due to the lack of effective treatments. B7-H4 is a newly characterized member of the B7 superfamily that is actively involved in regulating the pathogenesis of tumors. However, the intrahepatic expression of B7-H4 in HBV-HCC patients has not been described. In this study, we found that the higher expression of HBx and B7-H4 was correlated with tumor progression of HBV-HCC. Therefore, B7-H4 may be involved in facilitating HBV-related hepatocarcinogenesis.
Publish Date	2016-05-04 10:08
Citation	Hong B, Qian Y, Zhang H, Sang YW, Cheng LF, Wang Q, Gao S, Zheng M, Yao HP. Expression of B7-H4 and hepatitis B virus X in hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2016; 22(18): 4538-4546
URL	http://www.wjgnet.com/1007-9327/full/v22/i18/4538.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i18.4538

Full Article (PDF)	WJG-22-4538.pdf
Full Article (Word)	WJG-22-4538.doc
Manuscript File	24250-Review.doc
Answering Reviewers	24250-Answering reviewers.pdf
Audio Core Tip	24250-Audio core tip.mp3
Biostatistics Review Certificate	24250-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	24250-Conflict-of-interest statement.pdf
Copyright License Agreement	24250-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	24250-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	24250-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	24250-Language certificate.pdf
Peer-review Report	24250-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	24250-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	24250-Scientific misconduct check.pdf
Scientific Editor Work List	24250-Scientific editor work list.pdf