Publication Name	World Journal of Gastroenterology
Manuscript ID	24251
Country	Japan

Received	2016-01-14 17:01
Peer-Review Started	2016-01-16 18:21
To Make the First Decision	2016-03-21 08:33
Return for Revision	2016-03-23 15:09
Revised	2016-04-01 22:57
Second Decision	2016-04-07 12:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-04-15 14:06
Articles in Press	2016-04-15 14:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-19 13:54
Publish the Manuscript Online	2016-05-04 10:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Peer-review started: February 25, 2016
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Mikio Kajihara, Kazuki Takakura, Tomoya Kanai, Zensho Ito, Yoshihiro Matsumoto, Shigetaka Shimodaira, Masato Okamoto, Toshifumi Ohkusa and Shigeo Koido
Funding Agency and Grant Number
Corresponding Author	Shigeo Koido, MD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, the Jikei University School of Medicine (Kashiwa Hospital), 163-1 Kashiwashita, Kashiwa, Chiba 277-8567, Japan. shigeo_koido@jikei.ac.jp
Key Words	Pancreatic cancer; Dendritic cell; Whole tumor cell; Cancer vaccine; Cytotoxic T lymphocyte
Core Tip	Chemotherapy and cell-based cancer vaccines such as dendritic cell- and whole tumor cell-based cancer vaccines can synergize to result in increased efficacies in patients with pancreatic ductal adenocarcinoma (PDA). Moreover, cell-based cancer vaccines and immune checkpoint inhibitors can be used to block inhibitory ligand/receptor interactions by acting on certain cancer cells or T cells, allowing an enhancement of the antitumor immune response in specific tumors, including PDA. Therefore, the blockade of immune regulatory checkpoints combined with cell-based cancer vaccines and/or chemotherapy may be effective in inducing adaptive antitumor immunity in patients with PDA.
Publish Date	2016-05-04 10:08
Citation	Kajihara M, Takakura K, Kanai T, Ito Z, Matsumoto Y, Shimodaira S, Okamoto M, Ohkusa T, Koido S. Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer. World J Gastroenterol 2016; 22(18): 4446-4458
URL	http://www.wjgnet.com/1007-9327/full/v22/i18/4446.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i18.4446

Full Article (PDF)	WJG-22-4446.pdf
Full Article (Word)	WJG-22-4446.doc
Manuscript File	24251-Review.docx
Answering Reviewers	24251-Answering reviewers.pdf
Audio Core Tip	24251-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	24251-Conflict-of-interest statement.pdf
Copyright License Agreement	24251-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	24251-Language certificate.pdf
Peer-review Report	24251-Peer-review(s).pdf
Scientific Misconduct Check	24251-Scientific misconduct check.pdf
Scientific Editor Work List	24251-Scientific editor work list.pdf