Publication Name	World Journal of Orthopedics
Manuscript ID	2426
Country	Greece

Received	2013-02-21 09:30
Peer-Review Started	2013-02-21 19:46
First Decision by Editorial Office Director
Return for Revision	2013-05-20 10:17
Revised	2013-06-07 00:18
Publication Fee Transferred
Second Decision by Editor	2013-06-19 13:00
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-06-20 01:10
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-22 18:09
Publish the Manuscript Online	2013-10-28 15:24

ISSN	2218-5836 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Orthopedics
Manuscript Type	Case Report
Article Title	Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia
Manuscript Source	Invited Manuscript
All Author List	Haris S Vasiliadis, Christina Arnaoutoglou, Sotiris Plakoutsis, Michalis Doukas, Anna Batistatou and Theodoros A Xenakis
Funding Agency and Grant Number
Corresponding Author	Haris S Vasiliadis MD, PhD, Department of Orthopaedics, University Hospital of Ioannina, Panepistimiou 4, 45500 Ioannina, Greece. vasiliadismd@gmail.com
Key Words	Osteosarcoma; Fibrous dysplasia of bone; Distal femur; Custom-made total knee arthroplasty; Tumour
Core Tip	We report a case of a 32 year-old male, admitted for a lytic lesion of the distal femur. Although open biopsy suggested fibrous dysplasia, clinical and radiological evaluation indicated malignancy. Histological examination of the excised specimen revealed central low-grade osteosarcoma. Central low-grade osteosarcoma is a rare, well-differentiated, sub-type of osteosarcoma, with clinical, imaging, and histological features in keeping with benign tumours. Thus, initial misdiagnosis is common, typically being mistaken for fibrous dysplasia. Central low-grade osteosarcoma is usually treated with surgery in isolation, with rare cases of distal metastases. However, regional recurrence is quite frequent after close margin excision.
Publish Date	2013-10-28 15:24
Citation	Vasiliadis HS, Arnaoutoglou C, Plakoutsis S, Doukas M, Batistatou A, Xenakis TA. Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia. World J Orthop 2013; 4(4): 327-332
URL	http://www.wjgnet.com/2218-5836/full/v4/i4/327.htm
DOI	http://dx.doi.org/10.5312/wjo.v4.i4.327

Full Article (PDF)	WJO-4-327.pdf
Manuscript File	2426-Review.doc
Answering Reviewers	2426-Answering reviewers.pdf
Copyright License Agreement	2426-Copyright assignment.pdf
Peer-review Report	2426-Peer reviews.pdf
Scientific Editor Work List	2426-Scientific editor work list.doc