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5/30/2016 5:39:00 PM | Browse: 526 | Download: 1089
Publication Name World Journal of Gastroenterology
Manuscript ID 24263
Country/Territory China
2016-01-19 09:00
Peer-Review Started
2016-01-19 17:15
To Make the First Decision
2016-02-18 11:48
Return for Revision
2016-02-19 11:13
2016-03-04 15:04
Second Decision
2016-03-11 08:03
Accepted by Journal Editor-in-Chief
2016-03-13 08:02
Accepted by Company Editor-in-Chief
2016-03-18 17:29
Articles in Press
2016-03-18 17:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-03-30 16:51
Typeset the Manuscript
2016-04-29 15:22
Publish the Manuscript Online
2016-05-30 17:40
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title CdSe/ZnS quantum dots induce photodynamic effects and cytotoxicity in pancreatic cancer cells
Manuscript Source Unsolicited Manuscript
All Author List Si-Jia He, Jia Cao, Yong-Sheng Li, Jia-Chun Yang, Min Zhou, Chun-Ying Qu, Yi Zhang, Feng Shen, Ying Chen, Ming-Ming Li and Lei-Ming Xu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81472844
National Natural Science Foundation of China 81301826
Shanghai Municipal Education Commission 14ZZ114
Corresponding author Lei-Ming Xu, Chief Physician, Department of Gastroenterology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China. leiming.xu@aliyun.com
Keywords Quantum dots; Pancreatic cancer; Apoptosis; Photodynamic therapy; Reactive oxygen species
Core Tip This study showed that quantum dots (QDs) may be a potential photosensitizer for photodynamic therapy (PDT) to treat pancreatic cancer by inhibiting SW1990 cell proliferation and inducing apoptosis through reactive oxygen species (ROS) generation. QD-PDT may induce apoptosis through ROS-, caspase-3-mediated apoptotic pathways, with upregulation of apoptosis signaling molecules such as Bax and downregulation of Bcl-2. These findings provide a new application for PDT in pancreatic cancer. However, more preclinical and clinical trials should be undertaken before further clinical application.
Publish Date 2016-05-30 17:40
Citation He SJ, Cao J, Li YS, Yang JC, Zhou M, Qu CY, Zhang Y, Shen F, Chen Y, Li MM, Xu LM. CdSe/ZnS quantum dots induce photodynamic effects and cytotoxicity in pancreatic cancer cells. World J Gastroenterol 2016; 22(21): 5012-5022
Url http://www.wjgnet.com/1007-9327/full/v22/i21/5012.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i21.5012
Full Article (PDF) WJG-22-5012.pdf
Full Article (Word) WJG-22-5012.doc
Manuscript File 24263-Review.doc
Answering Reviewers 24263-Answering reviewers.pdf
Audio Core Tip 24263-Audio core tip.mp3
Biostatistics Review Certificate 24263-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 24263-Conflict-of-interest statement.pdf
Copyright License Agreement 24263-Copyright assignment.pdf
Data Sharing Statement 24263-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 24263-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 24263-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 24263-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 24263-Language certificate.PDF
Peer-review Report 24263-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 24263-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 24263-Scientific misconduct check.pdf
Scientific Editor Work List 24263-Scientific editor work list.pdf