| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
CdSe/ZnS quantum dots induce photodynamic effects and cytotoxicity in pancreatic cancer cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Si-Jia He, Jia Cao, Yong-Sheng Li, Jia-Chun Yang, Min Zhou, Chun-Ying Qu, Yi Zhang, Feng Shen, Ying Chen, Ming-Ming Li and Lei-Ming Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81472844 |
| National Natural Science Foundation of China |
81301826 |
| Shanghai Municipal Education Commission |
14ZZ114 |
|
| Corresponding Author |
Lei-Ming Xu, Chief Physician, Department of Gastroenterology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China. leiming.xu@aliyun.com |
| Key Words |
Quantum dots; Pancreatic cancer; Apoptosis; Photodynamic therapy; Reactive oxygen species |
| Core Tip |
This study showed that quantum dots (QDs) may be a potential photosensitizer for photodynamic therapy (PDT) to treat pancreatic cancer by inhibiting SW1990 cell proliferation and inducing apoptosis through reactive oxygen species (ROS) generation. QD-PDT may induce apoptosis through ROS-, caspase-3-mediated apoptotic pathways, with upregulation of apoptosis signaling molecules such as Bax and downregulation of Bcl-2. These findings provide a new application for PDT in pancreatic cancer. However, more preclinical and clinical trials should be undertaken before further clinical application. |
| Publish Date |
2016-05-30 17:40 |
| Citation |
He SJ, Cao J, Li YS, Yang JC, Zhou M, Qu CY, Zhang Y, Shen F, Chen Y, Li MM, Xu LM. CdSe/ZnS quantum dots induce photodynamic effects and cytotoxicity in pancreatic cancer cells. World J Gastroenterol 2016; 22(21): 5012-5022 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i21/5012.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i21.5012 |
