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Articles Published Processes
4/12/2016 1:04:00 PM | Browse: 1376 | Download: 2789
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Received |
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2016-01-15 08:17 |
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Peer-Review Started |
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2016-01-20 18:40 |
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To Make the First Decision |
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Return for Revision |
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Revised |
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Second Decision |
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2016-01-28 14:13 |
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Accepted by Journal Editor-in-Chief |
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2016-01-31 12:38 |
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Accepted by Executive Editor-in-Chief |
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2016-02-22 11:04 |
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Articles in Press |
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2016-02-22 11:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-03-02 04:27 |
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Typeset the Manuscript |
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2016-03-18 14:10 |
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Publish the Manuscript Online |
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2016-04-03 18:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Mir-30d increases intracellular survival of Helicobacter pylori through inhibition of autophagy pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Jun Yang, Ruo-Huang Si, Yu-He Liang, Bing-Qiang Ma, Ze-Bin Jiang, Bin Wang and Peng Gao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81260326 |
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| Corresponding Author |
Peng Gao, MD, Professor, Chief, Department of General Surgery, Gansu Provincial Hospital, No. 204 Donggang West Road, Lanzhou 730000, Gansu Province, China. gaopenglz@aliyun.com |
| Key Words |
mir-30d; Helicobacter pylori; Autophagy; Gene expression; Gastric cancer |
| Core Tip |
In this study, we tested a hypothesis that mir-30d could repress autophagy in response to Helicobacter pylori (H. pylori) invasion by directly targeting multiple core genes of the autophagy pathway, including ATG2B, ATG5, ATG12, BECN1 and BNIP3L in gastric epithelial cells. Inhibition of autophagy increased the intracellular survival of H. pylori in AGS cells, and the repression of autophagy by mir-30d may help the intracellular H. pylori to evade autophagic clearance. These findings provide a novel mechanism for elucidating persistent H. pylori infection and provide a promising target for gastric cancer prevention.
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| Publish Date |
2016-04-03 18:51 |
| Citation |
Yang XJ, Si RH, Liang YH, Ma BQ, Jiang ZB, Wang B, Gao P. Mir-30d increases intracellular survival of Helicobacter pylori through inhibition of autophagy pathway. World J Gastroenterol 2016; 22(15): 3978-3991 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i15/3978.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i15.3978 |
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