Publication Name	World Journal of Hepatology
Manuscript ID	24291
Country	Netherlands

Received	2016-01-16 15:17
Peer-Review Started	2016-01-19 09:11
To Make the First Decision	2016-02-29 15:37
Return for Revision	2016-03-07 18:40
Revised	2016-03-18 23:58
Second Decision	2016-03-28 08:50
Accepted by Journal Editor-in-Chief	2016-03-30 21:36
Accepted by Executive Editor-in-Chief	2016-08-08 14:42
Articles in Press	2016-08-08 14:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-12 17:26
Publish the Manuscript Online	2016-09-14 11:03

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Editorial
Article Title	Cholangiocarcinoma, gone without the Wnt?
Manuscript Source	Invited Manuscript
All Author List	Anne TR Noll, Thorsten Cramer, Steven WM Olde Damink and Frank G Schaap
Funding Agency and Grant Number
Corresponding Author	Frank G Schaap, PhD, Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, PO BOX 616, 6200 MD Maastricht, The Netherlands. frank.schaap@maastrichtuniversity.nl
Key Words	Intrahepatic cholangiocarcinoma; Liver neoplasms; Carcinogenesis; Wnt signaling pathway; Wnt7B protein; Wnt proteins
Core Tip	Cholangiocarcinoma (CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts with dismal prognosis. CCA frequently arises on a background of chronic liver inflammation and cholestasis, which creates a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accu-mulation of muta-tions, transformation and expansion of mutated cells. A recent elaborate study by Boulter et al (J Clin Invest 125:1269) has provided novel insights into the molecular pathogenesis of CCA. Involvement of the Wnt signaling pathway in cholangiocarcinogenesis, and effect of Wnt inhibitors on CCA development in vivo are discussed in this Editorial.
Publish Date	2016-09-14 11:03
Citation	Noll ATR, Cramer T, Olde Damink SWM, Schaap FG. Cholangiocarcinoma, gone without the Wnt? World J Hepatol 2016; 8(26): 1093-1096
URL	http://www.wjgnet.com/1948-5182/full/v8/i26/1093.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i26.1093

Full Article (PDF)	WJH-8-1093.pdf
Full Article (Word)	WJH-8-1093.doc
Manuscript File	24291-Review.doc
Answering Reviewers	24291-Answering reviewers.pdf
Audio Core Tip	24291-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	24291-Conflict-of-interest statement.pdf
Copyright License Agreement	24291-Copyright assignment.pdf
Peer-review Report	24291-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	24291-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	24291-Scientific misconduct check.pdf
Scientific Editor Work List	24291-Scientific editor work list.pdf