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Articles Published Processes
3/29/2016 3:29:00 PM | Browse: 1375 | Download: 2254
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Received |
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2016-01-18 15:17 |
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Peer-Review Started |
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2016-01-18 16:30 |
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To Make the First Decision |
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2016-02-18 16:56 |
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Return for Revision |
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2016-02-20 17:38 |
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Revised |
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2016-03-01 18:59 |
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Second Decision |
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2016-03-04 18:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-03-14 09:41 |
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Articles in Press |
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2016-03-14 09:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-03-22 11:03 |
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Publish the Manuscript Online |
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2016-03-29 15:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Case Control Study |
| Article Title |
Multi-locus genetic risk score predicts risk for Crohn’s disease in Slovenian population
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Katarina Zupančič, Kristijan Skok, Katja Repnik, Rinse K Weersma, Uroš Potočnik and Pavel Skok |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Slovenian National Committee for Medical Ethics |
KME 80/10/ 07 |
| Slovenian National Committee for Medical Ethics |
21p / 12/ 07 |
| Slovenian National Committee for Medical Ethics |
106/05/11 |
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| Corresponding Author |
Pavel Skok, MD, PhD, Full Professor, Department of Gastroenterology, University Medical Center, Ljubljanska ulica 5, 2000 Maribor, Slovenia. pavel.skok@guest.arnes.si |
| Key Words |
Inflammatory bowel disease; Crohn’s disease; Discriminatory accuracy; Genetic risk score; Single nucleotide polymorphisms |
| Core Tip |
Genome wide association studies have provided a comprehensive catalogue of susceptibility inflammatory bowel disease (IBD) loci, which now present an important basis for genetic risk prediction. We aimed to develop an accurate Crohn’s disease (CD) risk prediction model for the Slovenian cohort. The most optimal 33 SNPs model showed good discriminatory ability, which may be useful for risk stratification in targeted population (gastrointestinal disturbances, positive family history). Individuals in the highest risk group have 27-fold higher odds for CD risk compared to individuals in the lowest risk group. To the best of our knowledge, this is the first population specific genetic prediction based on recently established IBD loci. |
| Publish Date |
2016-03-29 15:29 |
| Citation |
Zupančič K, Skok K, Repnik K, Weersma RK, Potočnik U, Skok P. Multi-locus genetic risk score predicts risk for Crohn’s disease in Slovenian population. World J Gastroenterol 2016; 22(14): 3777-3784 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i14/3777.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i14.3777 |
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