Publication Name	World Journal of Medical Genetics
Manuscript ID	24321
Country	Kazakhstan

Received	2016-01-18 08:39
Peer-Review Started	2016-01-18 18:28
To Make the First Decision	2016-02-29 15:38
Return for Revision	2016-03-07 12:42
Revised
Second Decision	2016-07-28 14:45
Accepted by Journal Editor-in-Chief	2016-07-29 16:01
Accepted by Executive Editor-in-Chief	2016-08-08 14:43
Articles in Press	2016-08-08 14:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-19 16:22
Publish the Manuscript Online	2016-08-24 08:44

ISSN	2220-3184 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Engineering, Biomedical
Manuscript Type	Review
Article Title	Chitosan DNA nanoparticles for oral gene delivery
Manuscript Source	Unsolicited Manuscript
All Author List	Bhavika J Patel, Nithin K Vignesh and Gonzalo Hortelano
Funding Agency and Grant Number
Corresponding Author	Gonzalo Hortelano, PhD, Department of Biology, School of Science and Technology, Nazarbayev University, Astana 010000, Kazakhstan. gonzalo.hortelano@nu.edu.kz
Key Words	Gene therapy; Oral gene delivery; Chitosan nanoparticles; Glycocalyx; pH; Enzymes; Endolysosomal escape; Intracellular transport; Nuclear transport; Mucus
Core Tip	Gene therapy is facing considerable challenges to realize its promise, the most important which is arguably achieving effective delivery of the therapeutic gene to the target cells. Therefore, developing alternative delivery strategies is crucial. This manuscript reviews the oral administration of chitosan DNA nanoparticles as a novel gene therapy delivery strategy.
Publish Date	2016-08-24 08:44
Citation	Patel BJ, Vignesh NK, Hortelano G. Chitosan DNA nanoparticles for oral gene delivery. World J Med Genet 2016; 6(3): 22-33
URL	http://www.wjgnet.com/2220-3184/full/v6/i3/22.htm
DOI	http://dx.doi.org/10.5496/wjmg.v6.i3.22

Full Article (PDF)	WJMG-6-22.pdf
Full Article (Word)	WJMG-6-22.doc
Manuscript File	24321-Review.docx
Answering Reviewers	24321-Answering reviewers.pdf
Audio Core Tip	24321-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	24321-Conflict-of-interest statement.pdf
Copyright License Agreement	24321-Copyright assignment.pdf
Peer-review Report	24321-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	24321-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	24321-Scientific misconduct check.pdf
Scientific Editor Work List	24321-Scientific editor work list.pdf