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Publication Name World Journal of Gastroenterology
Manuscript ID 2438
Country of Manuscript Source Germany
Received
2013-02-21 10:17
Peer-Review Started
2013-02-22 08:40
To Make the First Decision
2013-03-18 15:32
Return for Revision
2013-03-19 11:59
Revised
2013-03-24 19:02
Second Decision
2013-04-17 10:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-04-17 11:12
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-05-16 18:31
Publish the Manuscript Online
2013-05-20 14:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Review
Article Title Herbal hepatotoxicity: Challenges and pitfalls of causality assessment methods
Manuscript Source Invited Manuscript
All Author List Rolf Teschke, Christian Frenzel, Johannes Schulze and Axel Eickhoff
Funding Agency and Grant Number
Corresponding author Rolf Teschke, MD, Professor of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine Ⅱ, Klinikum Hanau, Leimenstrasse 20, D-63450 Hanau, Germany. rolf.teschke@gmx.de
Keywords Herbal hepatotoxicity; Herb induced liver injury; Herbs; Drug hepatotoxicity; Drug induced liver injury; Causality assessment
Core Tip This review focuses on diagnostic causality assessment algorithms that have been used so far in herb induced liver injury (HILI) cases. Detailed information of the various methods with their strengths and weaknesses is provided including their challenges and pitfalls that emerged during the assessing course. For the physician caring for a patient with suspected HILI, the Council for International Organizations of Medical Sciences (CIOMS) scale is the preferred tool for assessing causality compared to numerous other causality assessment methods, which are inferior on various grounds. CIOMS based assessment should start at the day HILI is suspected to ensure completeness of clinical data.
Publish Date 2013-05-20 14:33
Citation Teschke R, Frenzel C, Schulze J, Eickhoff A. Herbal hepatotoxicity: Challenges and pitfalls of causality assessment methods. World J Gastroenterol 2013; 19(19): 2864-2882
Url http://www.wjgnet.com/1007-9327/full/v19/i19/2864.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i19.2864
Full Article (PDF) WJG-19-2864.pdf
Manuscript File 2438-Review.doc
Answering Reviewers 2438-Answering reviewers.doc
Copyright License Agreement 2438-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 2438-Language certificate.pdf
Peer-review Report 2438-Peer review(s).pdf
Scientific Editor Work List 2438-Scientific editor work list.doc