Publication Name	World Journal of Gastroenterology
Manuscript ID	2438
Country	Germany

Received	2013-02-21 10:17
Peer-Review Started	2013-02-22 08:40
To Make the First Decision	2013-03-18 15:32
Return for Revision	2013-03-19 11:59
Revised	2013-03-24 19:02
Second Decision	2013-04-17 10:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-04-17 11:12
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-16 18:31
Publish the Manuscript Online	2013-05-20 14:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Herbal hepatotoxicity: Challenges and pitfalls of causality assessment methods
Manuscript Source	Invited Manuscript
All Author List	Rolf Teschke, Christian Frenzel, Johannes Schulze and Axel Eickhoff
Funding Agency and Grant Number
Corresponding Author	Rolf Teschke, MD, Professor of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine Ⅱ, Klinikum Hanau, Leimenstrasse 20, D-63450 Hanau, Germany. rolf.teschke@gmx.de
Key Words	Herbal hepatotoxicity; Herb induced liver injury; Herbs; Drug hepatotoxicity; Drug induced liver injury; Causality assessment
Core Tip	This review focuses on diagnostic causality assessment algorithms that have been used so far in herb induced liver injury (HILI) cases. Detailed information of the various methods with their strengths and weaknesses is provided including their challenges and pitfalls that emerged during the assessing course. For the physician caring for a patient with suspected HILI, the Council for International Organizations of Medical Sciences (CIOMS) scale is the preferred tool for assessing causality compared to numerous other causality assessment methods, which are inferior on various grounds. CIOMS based assessment should start at the day HILI is suspected to ensure completeness of clinical data.
Publish Date	2013-05-20 14:33
Citation	Teschke R, Frenzel C, Schulze J, Eickhoff A. Herbal hepatotoxicity: Challenges and pitfalls of causality assessment methods. World J Gastroenterol 2013; 19(19): 2864-2882
URL	http://www.wjgnet.com/1007-9327/full/v19/i19/2864.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i19.2864

Full Article (PDF)	WJG-19-2864.pdf
Manuscript File	2438-Review.doc
Answering Reviewers	2438-Answering reviewers.doc
Copyright License Agreement	2438-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2438-Language certificate.pdf
Peer-review Report	2438-Peer review(s).pdf
Scientific Editor Work List	2438-Scientific editor work list.doc