Publication Name	World Journal of Hepatology
Manuscript ID	2443
Country	Brazil

Received	2013-02-21 11:18
Peer-Review Started	2013-02-22 10:12
To Make the First Decision	2013-03-11 15:04
Return for Revision	2013-03-17 19:05
Revised	2013-05-19 22:13
Second Decision	2013-06-03 11:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-06-04 08:27
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-18 15:07
Publish the Manuscript Online	2013-07-25 09:10

ISSN	1948-5182 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Autobiography
Article Title	In vivo assessment of intratumoral aspirin injection to treat hepatic tumors
Manuscript Source	Invited Manuscript
All Author List	Rogério Saad-Hossne, Fábio Vieira Teixeira and Rafael Denadai
Funding Agency and Grant Number
Corresponding Author	Rafael Denadai, MD, Division of Coloproctology, Department of Surgery, Botucatu Medical School, University of the State of São Paulo, Distrito de Rubião Júnior s/n, 18618-000 Botucatu-SP, Brazil. denadai.rafael@hotmail.com
Key Words	Intralesional injection; Intratumoral injection; Aspirin; Hepatic tumor; VX2; Rabbit; Antineoplastic; Therapy
Core Tip	This experimental study employed the well-established VX2 hepatic tumor rabbit model to assess the antineoplastic efficacy of intratumoral aspirin injection. Analysis of early (24 h post-treatment) and late (7 d post-treatment) effects indicated that the therapy caused early tumor destruction, as evidenced by significant necrotic areas in histopathological analysis, without late recurrence, as demonstrated by hepatic tissue regeneration and restoration of liver function biochemical parameters.
Publish Date	2013-07-25 09:10
Citation	Saad-Hossne R, Teixeira FV, Denadai R. In vivo assessment of intratumoral aspirin injection to treat hepatic tumors. World J Hepatol 2013; 5(7): 372-378
URL	http://www.wjgnet.com/1948-5182/full/v5/i7/372.htm
DOI	http://dx.doi.org/10.4254/wjh.v5.i7.372

Full Article (PDF)	WJH-5-372.pdf
Manuscript File	2443-Review.doc
Answering Reviewers	2443 Answering Reviewers.doc
Copyright License Agreement	2443-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2443-Language certificate.pdf
Peer-review Report	2443-Peer review(s).pdf
Scientific Editor Work List	2443-Scientific editor work list.doc