Publication Name	World Journal of Hepatology
Manuscript ID	24432
Country	United Kingdom

Received	2016-01-22 09:29
Peer-Review Started	2016-01-23 08:47
To Make the First Decision	2016-02-22 10:21
Return for Revision	2016-02-22 14:30
Revised	2016-03-02 02:28
Second Decision	2016-03-07 15:35
Accepted by Journal Editor-in-Chief	2016-03-09 16:31
Accepted by Executive Editor-in-Chief	2016-03-16 16:09
Articles in Press	2016-03-16 16:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-24 16:47
Publish the Manuscript Online	2016-03-30 15:59

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatocellular carcinoma: Review of disease and tumor biomarkers
Manuscript Source	Invited Manuscript
All Author List	Jin Un Kim, Mohamed I F Shariff, Mary M E Crossey, Maria Gomez-Romero, Elaine Holmes, I Jane Cox, Haddy K S Fye, Ramou Njie and Simon D Taylor-Robinson
Funding Agency and Grant Number
Corresponding Author	Jin Un Kim, BSc, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, St Mary’s Campus, South Wharf Road, London W2 1NY, United Kingdom. juk11@ic.ac.uk
Key Words	Hepatocellular carcinoma; Biomarker; Metabonomics; Warburg hypothesis; Serum; Plasma; Urine
Core Tip	Many independent authors have utilized quan-titative techniques, such as 1H nuclear magnetic resonance and mass spectrometry to discover novel biomarkers to aid early diagnosis, following the removal of alpha fetoprotein from international surveillance guidelines. However, relatively little effort has been directed to translate these findings to the clinical setting. hepatocellular carcinoma (HCC) is a global issue and the vast majority of the burden is placed upon resource-limited regions, where presentations are late and management techniques for advanced tumors are unavailable. Early identification through a simple serum or urinary investigation, therefore, may be a pivotal step in addressing the global burden of HCC.
Publish Date	2016-03-30 15:59
Citation	Kim JU, Shariff MIF, Crossey MME, Gomez-Romero M, Holmes E, Cox IJ, Fye HKS, Njie R, Taylor-Robinson SD. Hepatocellular carcinoma: Review of disease and tumor biomarkers. World J Hepatol 2016; 8(10): 471-484
URL	http://www.wjgnet.com/1948-5182/full/v8/i10/471.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i10.471

Full Article (PDF)	WJH-8-471.pdf
Full Article (Word)	WJH-8-471.doc
Manuscript File	24432-Review.docx
Answering Reviewers	24432-Answering reviewers.pdf
Audio Core Tip	24432-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	24432-Conflict-of-interest statement.pdf
Copyright License Agreement	24432-Copyright assignment.pdf
Peer-review Report	24432-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	24432-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	24432-Scientific misconduct check.pdf
Scientific Editor Work List	24432-Scientific editor work list.pdf