| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Prospective Study |
| Article Title |
Is neutrophil gelatinase associated lipocalin useful in hepatitis C virus infection?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alessio Strazzulla, Giuseppe Coppolino, Concetta Di Fatta, Francesca Giancotti, Giuseppina D’Onofrio, Maria Concetta Postorino, Maria Mazzitelli, Selma Valerie Mammone, Innocenza Gentile, Laura Rivoli, Eleonora Palella, Tiziana Gravina, Chiara Costa, Vincenzo Pisani, Vincenzo De Maria, Giorgio Settimo Barreca, Nadia Marascio, Alfredo Focà, Giorgio Fuiano, Elio Gulletta and Carlo Torti |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Dr. Alessio Strazzulla, Infectious Diseases Unit, Department of Medical and Surgical Sciences, “Magna Graecia” University, Unità Operativa Malattie Infettive, Policlinico “Mater Domini”, viale Europa, 88100 Catanzaro,
Italy. alessiostrazzulla@yahoo.it
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| Key Words |
Directly acting antivirals; Hepatitis C virus; Inflammation; Neutrophil gelatinase lipocalin; Tubular impairment |
| Core Tip |
For the first time, we evaluated the evolution of neutrophil gelatinase associated lipocalin (NGAL), a novel biomarker of renal impairment, in patients in-fected by hepatitis C virus before and during treatment with directly acting antivirals (DAAs). In our study, we documented a significant increase of NGAL during the first 12 wk of therapy with DAAs and a correlation of NGAL with both age and estimated glomerular filtration rate before starting treatment. In a context of paucity of information about safety of the new DAAs, we believe that these data are both informative and novel, provoking urgent investigations. |
| Publish Date |
2016-07-06 09:19 |
| Citation |
Strazzulla A, Coppolino G, Di Fatta C, Giancotti F, D’Onofrio G, Postorino MC, Mazzitelli M, Mammone SV, Gentile I, Rivoli L, Palella E, Gravina T, Costa C, Pisani V, De Maria V, Barreca GS, Marascio N, Focà A, Fuiano G, Gulletta E, Torti C. Is neutrophil gelatinase associated lipocalin a useful marker in hepatitis C virus infection? World J Hepatol 2016; 8(19): 815-824 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i19/815.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i19.815 |
