Publication Name	World Journal of Gastroenterology
Manuscript ID	24522
Country	Italy

Received	2016-01-26 08:58
Peer-Review Started	2016-01-27 12:57
To Make the First Decision	2016-03-07 09:31
Return for Revision	2016-03-08 09:46
Revised	2016-03-18 17:16
Second Decision	2016-03-22 17:36
Accepted by Journal Editor-in-Chief	2016-03-22 19:52
Accepted by Executive Editor-in-Chief	2016-03-30 17:07
Articles in Press	2016-03-30 17:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-01 16:22
Publish the Manuscript Online	2016-07-15 15:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Prospective Study
Article Title	Total and not bevacizumab-bound vascular endothelial growth factor as potential predictive factors to bevacizumab-based chemotherapy in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Amalia Azzariti, Letizia Porcelli, Oronzo Brunetti, Marzia Del Re, Vito Longo, Patrizia Nardulli, Michele Signorile, Jian-Ming Xu, Angela Calabrese, Anna Elisa Quatrale, Evaristo Maiello, Vito Lorusso and Nicola Silvestris
Funding Agency and Grant Number
Corresponding Author	Nicola Silvestris, MD, Medical Oncology Unit, National Cancer Research Centre Istituto Tumori Giovanni Paolo II, Viale Orazio Flacco, 65, 70124 Bari, Italy. n.silvestris@oncologico.bari.it
Key Words	Bevacizumab; Vascular endothelial growth factor; Angiopoietin 2; Metastatic colorectal cancer; Biomarker; Predictive factor
Core Tip	In the main topic of the identification of possible reliable markers to predict response to anti-angiogenic therapy, our paper represents an original contribution describing the role of not bevacizumab (BV)-bound vascular endothelial growth factor (VEGF)/total VEGF ratio and of bevacizumab serum level as predictors of response in a consecutive series of patients with metastatic colorectal cancer. In this paper the rediscovery of the predictive role of traditional biomarkers as not BV-bound VEGF/total VEGF plasma ratio together with the results of the bevacizumab pharmacokinetic in response, stable disease and progression settings of patients with metastatic colorectal cancer treated with bevacizumab plus oxaliplatin based chemotherapy supported our hypothesis.
Publish Date	2016-07-15 15:38
Citation	Azzariti A, Porcelli L, Brunetti O, Del Re M, Longo V, Nardulli P, Signorile M, Xu JM, Calabrese A, Quatrale AE, Maiello E, Lorusso V, Silvestris N. Total and not bevacizumab-bound vascular endothelial growth factor as potential predictive factors to bevacizumab-based chemotherapy in colorectal cancer. World J Gastroenterol 2016; 22(27): 6287-6295
URL	http://www.wjgnet.com/1007-9327/full/v22/i27/6287.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i27.6287

Full Article (PDF)	WJG-22-6287.pdf
Full Article (Word)	WJG-22-6287.doc
Manuscript File	24522-Review.docx
Answering Reviewers	24522-Answering reviewers.pdf
Audio Core Tip	24522-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	24522-Conflict-of-interest statement.pdf
Copyright License Agreement	24522-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160126023037.docx
Non-Native Speakers of English Editing Certificate	24522-Language certificate.pdf
Peer-review Report	24522-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	24522-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	24522-Scientific misconduct check.pdf
Scientific Editor Work List	24522-Scientific editor work list.pdf