Publication Name	World Journal of Gastroenterology
Manuscript ID	24548
Country	South Korea

Received	2016-01-27 08:35
Peer-Review Started	2016-01-28 12:21
To Make the First Decision	2016-03-21 09:32
Return for Revision	2016-03-22 10:32
Revised	2016-04-01 13:46
Second Decision	2016-04-13 07:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-04-20 14:16
Articles in Press	2016-04-20 14:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-27 17:36
Publish the Manuscript Online	2016-05-17 10:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Recent updates of precision therapy for gastric cancer: Towards optimal tailored management
Manuscript Source	Invited Manuscript
All Author List	Moon Kyung Joo, Jong-Jae Park and Hoon Jai Chun
Funding Agency and Grant Number
Corresponding Author	Hoon Jai Chun, MD, PhD, AGAF, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, 126-1, Anam-dong 5 ga, Seongbuk-gu, Seoul 02841, South Korea. drchunhj@chol.com
Key Words	Gastric cancer; Hepatocyte growth factor; Mammalian target of rapamycin; Signal transducer and activator of transcription 3; Programmed cell death ligand-1
Core Tip	Among various cellular signaling pathways, hepatocyte growth factor/c-MET, phosphoinositide 3-kinase/Akt/mammalian target of rapamycin and janus kinase 2/signal transducer and activator of transcription 3 pathways are reportedly important in gastric carcinogenesis and metastasis. Aberrations of immune checkpoints have been vigorously investigated. However, clinical results of their target agents have not always matched the theoretical expectations of efficacy. In this review, we summarize the biologic impacts of the aforementioned signaling pathways, and their recent clinical outcomes including those of multiple kinase inhibitors in gastric cancer.
Publish Date	2016-05-17 10:45
Citation	Joo MK, Park JJ, Chun HJ. Recent updates of precision therapy for gastric cancer: Towards optimal tailored management. World J Gastroenterol 2016; 22(19): 4638-4650
URL	http://www.wjgnet.com/1007-9327/full/v22/i19/4638.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i19.4638

Full Article (PDF)	WJG-22-4638.pdf
Full Article (Word)	WJG-22-4638.doc
Manuscript File	24548-Review.doc
Answering Reviewers	24548-Answering reviewers.pdf
Audio Core Tip	24548-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	24548-Conflict-of-interest statement.pdf
Copyright License Agreement	24548-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	24548-Language certificate.pdf
Peer-review Report	24548-Peer-review(s).pdf
Scientific Misconduct Check	24548-Scientific misconduct check.pdf
Scientific Editor Work List	24548-Scientific editor work list.pdf