Publication Name	World Journal of Gastroenterology
Manuscript ID	2456
Country	Egypt

Received	2013-02-22 09:26
Peer-Review Started	2013-02-22 11:13
To Make the First Decision	2013-03-11 15:05
Return for Revision	2013-03-17 19:21
Revised	2013-03-29 06:32
Second Decision	2013-05-18 16:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-05-19 23:51
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-17 20:23
Publish the Manuscript Online	2013-06-27 17:20

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Non-viral factors contributing to hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Manal A Hamed and Sanaa A Ali
Funding Agency and Grant Number
Corresponding Author	Sanaa A Ali, Professor of Biochemistry, Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Division, National Research Centre, El-Behooth St., Dokki, Cairo 12622, Egypt. sanaa_ahmedibrahim@yahoo.com
Key Words	Hepatocellular carcinoma; Viral etiologic factors; Non viral factors
Core Tip	Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers worldwide, there are multiple non-viral factors have been implicated in the development of HCC, hemochromatosis, obesity, diabetes, alcohol and tobacco have consistently been shown to dramatically increase the rate of HCC. Oral contraceptive, aflatoxin, pesticides exposure and betel quid chewing also increase HCC risk, in addition, Wilson disease, ?-1 antitrypsin deficiency, porphyries, autoimmune hepatitis, Schistosoma japonicum infection associated with positive hepatitis B surface antigen, and thorotrast-ray are contributing in the prevalence of the disease. Moreover, primary biliary cirrhosis, congestive liver disease and family history of liver cancer play a significant role of disease progression.
Publish Date	2013-06-27 17:20
Citation	Hamed MA, Ali SA. Non-viral factors contributing to hepatocellular carcinoma. World J Hepatol 2013; 5(6): 311-322
URL	http://www.wjgnet.com/1948-5182/full/v5/i6/311.htm
DOI	http://dx.doi.org/10.4254/wjh.v5.i6.311

Full Article (PDF)	WJH-5-311.pdf
Manuscript File	2456-Review.doc
Answering Reviewers	2454-Answering reviewers.doc
Copyright License Agreement	2454-Copyright assignment.PDF
Peer-review Report	2456-Peer review(s).pdf
Scientific Editor Work List	2456-Scientific editor work list.doc