Publication Name	World Journal of Hepatology
Manuscript ID	24677
Country	France

Received	2016-02-01 09:14
Peer-Review Started	2016-02-01 17:10
First Decision by Editorial Office Director
Return for Revision	2016-03-25 16:27
Revised	2016-04-30 21:48
Publication Fee Transferred
Second Decision by Editor	2016-05-18 08:58
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-06-03 16:12
Articles in Press	2016-06-03 16:12
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-24 09:43
Publish the Manuscript Online	2016-07-06 09:19

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Virology
Manuscript Type	Basic Study
Article Title	Assembly and release of infectious hepatitis C virus involving unusual organization of the secretory pathway
Manuscript Source	Invited Manuscript
All Author List	Miriam Triyatni, Edward A Berger and Bertrand Saunier
Funding Agency and Grant Number	Funding Agency Grant Number Intramural Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases 1 ZIA AI000733-15 RISE Senior Fellow award 1238-1238-03
Corresponding Author	Bertrand Saunier, MD, PhD, Unité de Virologie Structurale, Institut Pasteur and CNRS UMR 3569, Centre François Jacob, 28 rue du Docteur Roux, 75724 Paris, France. bsaunier@pasteur.fr
Key Words	Membrane rearrangements; Hepatitis C virus; Flavivirus replicon; Virus assembly and secretion; Host cellular factors
Core Tip	Our system for production of authentic infec-tious hepatitis C virus (HCV) in non-humanized, non-hepatic cells involves the rearrangement of inner cellular membranes triggered by the replication of flaviviruses. The present results suggest that this feature relies on the re-wiring of host factors that usually contribute to the secretion of glycoproteins to generate an unusual secretory pathway. This model offers a new way to study the properties of free HCV particles, i.e., indepen-dently from lipoproteins.
Publish Date	2016-07-06 09:19
Citation	Triyatni M, Berger EA, Saunier B. Assembly and release of infectious hepatitis C virus involving unusual organization of the secretory pathway. World J Hepatol 2016; 8(19): 796-814
URL	http://www.wjgnet.com/1948-5182/full/v8/i19/796.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i19.796

Full Article (PDF)	WJH-8-796.pdf
Full Article (Word)	WJH-8-796.doc
Manuscript File	24677-Review.docx
Answering Reviewers	24677-Answering reviewers.pdf
Audio Core Tip	24677-Audio core tip.aif
Biostatistics Review Certificate	24677-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	24677-Conflict-of-interest statement.pdf
Copyright License Agreement	24677-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	24677-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	24677-Institutional review board statement.pdf
Peer-review Report	24677-Peer-review(s).pdf
Scientific Misconduct Check	24677-Scientific misconduct check.pdf
Scientific Editor Work List	24677-Scientific editor work list.pdf