Publication Name	World Journal of Gastroenterology
Manuscript ID	24719
Country	South Korea

Received	2016-02-02 09:12
Peer-Review Started	2016-02-02 09:31
First Decision by Editorial Office Director
Return for Revision	2016-03-08 16:21
Revised	2016-03-21 10:42
Publication Fee Transferred
Second Decision by Editor	2016-03-30 16:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-04-07 16:04
Articles in Press	2016-04-07 16:04
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-12 12:28
Publish the Manuscript Online	2016-06-13 09:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Danbi Lee, Heather Lyu, Young-Hwa Chung, Jeong A Kim, Priya Mathews, Elizabeth Jaffee, Lei Zheng, Eunsil Yu, Young Joo Lee and Soo Hyung Ryu
Funding Agency and Grant Number
Corresponding Author	Young-Hwa Chung, MD, PhD, Depart­ment of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. yhchung@amc.seoul.kr
Key Words	Hepatocellular carcinoma; Chronic hepatitis B; Genomic change; Hepatitis B virus; Genotype C
Core Tip	In the present study, we determined the genomic changes in the X, S, basal core promoter (BCP), and precore regions of hepatitis B virus (HBV), and evaluate their role in the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients with genotype C HBV. As the results, it was suggested that T1753V mutation in X region might significantly increase the risk of HCC development in CHB patients with genotype C HBV. Also, the BCP mutations might act in synergy with T1753V or G1896A mutation, and with pre-S deletion to promote the development of HCC in these patients.
Publish Date	2016-06-13 09:14
Citation	Lee D, Lyu H, Chung YH, Kim JA, Mathews P, Jaffee E, Zheng L, Yu E, Lee YJ, Ryu SH. Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma. World J Gastroenterol 2016; 22(23): 5393-5399
URL	http://www.wjgnet.com/1007-9327/full/v22/i23/5393.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i23.5393

Full Article (PDF)	WJG-22-5393.pdf
Full Article (Word)	WJG-22-5393.doc
Manuscript File	24719-Review.docx
Answering Reviewers	24719-Answering reviewers.pdf
Audio Core Tip	24719-Audio core tip.mp3
Biostatistics Review Certificate	24719-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	24719-Conflict-of-interest statement.pdf
Copyright License Agreement	24719-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	24719-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	24719-Language certificate.pdf
Peer-review Report	24719-Peer-review(s).pdf
Scientific Misconduct Check	24719-Scientific misconduct check.pdf
Scientific Editor Work List	24719-Scientific editor work list.pdf