Publication Name	World Journal of Translational Medicine
Manuscript ID	24723
Country	United States

Received	2016-02-02 10:19
Peer-Review Started
To Make the First Decision
Return for Revision
Revised
Second Decision	2016-02-17 09:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-03-09 12:55
Articles in Press	2016-03-09 12:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-05 15:32
Publish the Manuscript Online	2016-04-11 10:17

ISSN	2220-6132 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Review
Article Title	Gene editing for corneal disease management
Manuscript Source	Invited Manuscript
All Author List	Sudhanshu P Raikwar, Apoorva S Raikwar, Shyam S Chaurasia and Rajiv R Mohan
Funding Agency and Grant Number	Funding Agency Grant Number Veteran Health Affairs Merit grant 1I01BX000357-05 (to Mohan RR) National Eye Institute, NIH grant R01EY017294 (to Mohan RR) Ruth M. Kraeuchi Missouri Endowment of Ophthalmology (to Mohan RR)
Corresponding Author	Rajiv R Mohan, PhD, FARVO, Pro­fessor, Ophthalmology and Molecular Medicine, One-health One-Medicine Ophthalmology and Vision Research, University of Missouri, 1600 E. Rollins Road, Columbia, MO 65211, United States. mohanr@health.missouri.edu
Key Words	Adeno-associated virus; Clustered Regularly-Interspaced Short Palindromic Repeats associated protein 9; Cornea; Clustered Regularly Interspaced Short Palindromic Repeat; Double strand breaks; Gene editing; sgRNA; Gene targeting; Homology directed repair; Homologous recombination; Indels; Lentiviral vector; Protospacer-adjacent motif; Transcription activator like effector nucleases; Zinc finger nucleases
Core Tip	Gene editing technology including clustered regularly interspaced short palindromic repeats/Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9, zinc finger nucleases, or transcription activator like effector nucleases has great potential for generating in vitro and in vivo models of corneal diseases including keratoconus and Fuchs’ endothelial corneal dystrophy. Furthermore, gene editing is a powerful tool for studying molecular mechanisms mediating corneal development, pathogenesis and developing next generation innovative gene therapies including the patient-specific personalized medicine for curing corneal diseases. This review discusses current status and latest developments in the field of gene editing. Gene editing based molecular therapy has the potential to revolutionize current pra-ctices in ophthalmology clinic for curing corneal blind-ness.
Publish Date	2016-04-11 10:17
Citation	Raikwar SP, Raikwar AS, Chaurasia SS, Mohan RR. Gene editing for corneal disease management. World J Transl Med 2016; 5(1): 1-13
URL	http://www.wjgnet.com/2220-6132/full/v5/i1/1.htm
DOI	http://dx.doi.org/10.5528/wjtm.v5.i1.1

Full Article (PDF)	WJTM-5-1.pdf
Full Article (Word)	WJTM-5-1.doc
Manuscript File	22876-Review.docx
Answering Reviewers	22876-Answering reviewers.pdf
Audio Core Tip	22876-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	22876-Conflict-of-interest statement.pdf
Copyright License Agreement	22876-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	22876-Grant application form(s).pdf
Peer-review Report	22876-Peer-review(s).pdf
Scientific Misconduct Check	22876-Scientific misconduct check.pdf
Scientific Editor Work List	22876-Scientific editor work list.pdf