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Articles Published Processes
5/30/2016 5:39:00 PM | Browse: 1397 | Download: 3451
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Received |
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2016-02-02 14:29 |
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Peer-Review Started |
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2016-02-03 08:00 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-03-08 16:27 |
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Revised |
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2016-03-14 16:29 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-03-17 14:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2016-03-30 17:05 |
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Articles in Press |
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2016-03-30 17:05 |
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Edit the Manuscript by Language Editor |
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2016-05-04 10:54 |
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Typeset the Manuscript |
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2016-05-18 09:51 |
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Publish the Manuscript Online |
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2016-05-30 17:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
125I-labeled anti-bFGF monoclonal antibody inhibits growth of hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng-Hui Hu, Lan-Hong Pan, Patrick Ting-Yat Wong, Wen-Hui Chen, Yan-Qing Yang, Hong Wang, Jun-Jian Xiang and Meng Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81273814 |
| Guangdong Province Key Scientific Research Grant |
2013A022100031 |
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| Corresponding Author |
Meng Xu, MD, PhD, Department of Oncology, the First Affiliated Hospital, Jinan University, No. 613 Huangpu Avenue West, Guangzhou 510632, Guangdong Province, China. xumengjinan@yahoo.com |
| Key Words |
Basic fibroblast growth factor; 125Iodine; Monoclonal antibody; Hepatocellular carcinoma; Fibroblast growth factor receptor; Vascular endothelial growth factor |
| Core Tip |
The aim of this study was to investigate the inhibitory efficacy of 125I-basic fibroblast growth factor (bFGF) monoclonal antibody (mAb) in mice with hepatocellular carcinoma (HCC). 125I-bFGF mAb inhibited the growth of HCC xenografts (P < 0.05). The combination of 125I and bFGF mAb was more effective than the concomitant use of 125I and bFGF mAb. 125I-bFGF mAb also significantly reduced the expression of bFGF and fibroblast growth factor receptor (FGFR) mRNA (P < 0.05). Moreover, 125I-bFGF mAb downregulated platelet-derived growth factor mRNA and upregulated vascular endothelial growth factor mRNA. |
| Publish Date |
2016-05-30 17:40 |
| Citation |
Hu PH, Pan LH, Wong PTY, Chen WH, Yang YQ, Wang H, Xiang JJ, Xu M. 125I-labeled anti-bFGF monoclonal antibody inhibits growth of hepatocellular carcinoma. World J Gastroenterol 2016; 22(21): 5033-5041 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i21/5033.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i21.5033 |
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