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Articles Published Processes
9/15/2014 8:54:00 PM | Browse: 1086 | Download: 1037
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Received |
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2013-02-22 14:40 |
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Peer-Review Started |
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2013-02-26 08:54 |
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First Decision by Editorial Office Director |
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2013-03-06 18:24 |
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Revised |
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2013-03-26 22:25 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2013-06-18 10:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2013-06-19 00:21 |
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Articles in Press |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2013-07-18 15:53 |
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Publish the Manuscript Online |
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2013-08-06 09:19 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Clinical utility of anti-p53 auto-antibody: Systematic review and focus on colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Aravind Suppiah and John Greenman |
| Funding Agency and Grant Number |
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| Corresponding Author |
Aravind Suppiah, MD, FRCS, Castle Hill Hospital, Castle Road, Cottingham HU16 5JQ, United Kingdom. aravind.suppiah@hotmail.com
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| Key Words |
p53 gene; p53 mutation; Anti-p53 auto-antibody; Cancer; Colorectal cancer |
| Core Tip |
Anti-p53 auto-antibodies are commonly produced in response to p53 mutations. Anti-p53 auto-antibody titres generally increase with tumour load, but not all patients who are initially sero-negative develop an auto-antibody response despite disease progression and metastases. Conversely, sero-positive patients do not lose their anti-p53 auto-antibodies despite the cancer being completely excised. In general, cancers with the highest p53 mutation rate, e.g., oesophageal and ovarian, demonstrate the highest anti-p53 auto-antibody rates; conversely, melanoma and testicular carcinoma with the lowest mutation rate have the lowest serum auto-antibody levels. Measurement of anti-p53 auto-antibodies may be useful in screening or monitoring for tumour recurrence.
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| Publish Date |
2013-08-06 09:19 |
| Citation |
Suppiah A, Greenman J. Clinical utility of anti-p53 auto-antibody: Systematic review and focus on colorectal cancer. World J Gastroenterol 2013; 19(29): 4651-4670 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i29/4651.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i29.4651 |
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