Publication Name	World Journal of Nephrology
Manuscript ID	24818
Country	Australia

Received	2016-02-10 15:02
Peer-Review Started	2016-02-14 15:19
To Make the First Decision	2016-03-21 13:58
Return for Revision	2016-03-21 18:40
Revised	2016-03-31 10:54
Second Decision	2016-04-06 16:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-04-18 11:55
Articles in Press	2016-04-18 11:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-20 17:27
Publish the Manuscript Online	2016-06-29 09:02

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats
Manuscript Source	Invited Manuscript
All Author List	Michelle HT Ta, Kristina G Schwensen, David Liuwantara, David L Huso, Terry Watnick and Gopala K Rangan
Funding Agency and Grant Number	Funding Agency Grant Number National Health and Medical Research Council of Australia 457575 Baltimore Polycystic Kidney Disease Research and Clinical Core Center P30DK090868 National Health and Medical Research Council of Australia 632647 Baltimore Polycystic Kidney Disease Research and Clinical Core Center DK095036
Corresponding Author	Gopala K Rangan, MBBS, PhD, Associate Professor of Medicine, Centre for Transplant and Renal Research, Westmead Institute for Medical Research and the University of Sydney, Level 5, 176 Hawkesbury Road (PO Box 412), Westmead, Sydney 2145, Australia. g.rangan@sydney.edu.au
Key Words	Inflammation; Nuclear factor-κB; Polycystic kidney disease; Tumour necrosis factor alpha; Chemokine CCL2
Core Tip	Until now, there has been limited information regarding the specific nuclear factor (NF)-κB proteins involved in polycystic kidney disease (PKD) and their expression throughout disease progression. Our study demonstrated that a diverse array of NF-κB proteins is expressed in the renal cyst-lining cells of a chronic rodent model of PKD, and that NF-κB expression is constitutive over time. NF-κB was also identified in human PKD, suggesting that NF-κB upregulation is common to renal cystic disease models. Our data suggest that components of both the canonical and non-canonical NF-κB pathway are upregulated in PKD. Future studies should be directed at verifying whether specific NF-κB inhibition can attenuate interstitial inflammation and cyst growth, and slow the decline in renal function in in vivo models of PKD.
Publish Date	2016-06-29 09:02
Citation	Ta MHT, Schwensen KG, Liuwantara D, Huso DL, Watnick T, Rangan GK. Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats. World J Nephrol 2016; 5(4): 339-357
URL	http://www.wjgnet.com/2220-6124/full/v5/i4/339.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i4.339

Full Article (PDF)	WJN-5-339.pdf
Full Article (Word)	WJN-5-339.doc
Manuscript File	24818-Review.docx
Answering Reviewers	24818-Answering reviewers.pdf
Audio Core Tip	24818-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	24818-Conflict-of-interest statement.pdf
Copyright License Agreement	24818-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	24818-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	24818-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	24818-Institutional review board statement.pdf
Supplementary Material	Supplementary_Material_20160210101453.docx
Peer-review Report	24818-Peer-review(s).pdf
Scientific Misconduct Check	24818-Scientific misconduct check.pdf
Scientific Editor Work List	24818-Scientific editor work list.pdf