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6/2/2016 3:42:00 PM | Browse: 820 | Download: 849
Publication Name World Journal of Hepatology
Manuscript ID 24837
Country/Territory Denmark
Received
2016-02-12 10:14
Peer-Review Started
2016-02-12 19:45
To Make the First Decision
2016-03-09 10:03
Return for Revision
2016-03-11 12:50
Revised
2016-04-01 18:43
Second Decision
2016-04-06 12:11
Accepted by Journal Editor-in-Chief
2016-04-08 11:22
Accepted by Company Editor-in-Chief
2016-04-22 16:56
Articles in Press
2016-04-22 16:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-05-19 09:53
Publish the Manuscript Online
2016-06-02 15:41
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy
Manuscript Source Unsolicited Manuscript
All Author List Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Kristoffer Tobias Gustav Rigbolt, Kirstine Sloth Tølbøl, Jonathan David Roth, Jacob Jelsing, Niels Vrang and Michael Feigh
Funding Agency and Grant Number
Corresponding author Michael Feigh, PhD, Gubra Aps, Hørsholm Kongevej 11B, 2970 Hørsholm, Denmark. mfe@gubra.dk
Keywords Nonalcoholic steatohepatitis; Liver biopsy; Diet-induced obesity; Nonalcoholic fatty liver disease; Fibrosis
Core Tip We characterize the development and pro-gression of diet-induced nonalcoholic steatohepatitis (NASH) in a wild-type and a genetically obese mouse model. We confirm that a diet high in trans-fat, fructose and cholesterol, develops key histological hallmarks of NASH (steatosis, inflammation, ballooning degeneration) in conjunction with fibrosis. Concomitantly, marked alterations in NASH associated gene expression path-ways can be evaluated by RNAseq analysis. In addition, we describe that performing a baseline liver biopsy enables individual disease staging for subsequent stratified randomization of animals into study groups. Finally, we show these models′ utility for a chronic repeated dosing study to evaluate pharmacological intervention.
Publish Date 2016-06-02 15:41
Citation Kristiansen MNB, Veidal SS, Rigbolt KTG, Tølbøl KS, Roth JD, Jelsing J, Vrang N, Feigh M. Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy. World J Hepatol 2016; 8(16): 673-684
Url http://www.wjgnet.com/1948-5182/full/v8/i16/673.htm
DOI http://dx.doi.org/10.4254/wjh.v8.i16.673
Full Article (PDF) WJH-8-673.pdf
Full Article (Word) WJH-8-673.doc
Manuscript File 24837-Review.docx
Answering Reviewers 24837-Answering reviewers.pdf
Audio Core Tip 24837-Audio core tip.mp3
Biostatistics Review Certificate 24837-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 24837-Conflict-of-interest statement.pdf
Copyright License Agreement 24837-Copyright assignment.pdf
Data Sharing Statement 24837-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 24837-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 24837-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 24837-Language certificate.pdf
Peer-review Report 24837-Peer-rerview(s).pdf
Journal Editor-in-Chief Review Report 24837-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 24837-Scientific misconduct check.pdf
Scientific Editor Work List 24837-Scientific editor work list.pdf