| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
|
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Hepatitis B surface antigen clearance in inactive hepatitis B surface antigen carriers treated with peginterferon alfa-2a
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ming-Hui Li, Yao Xie, Lu Zhang, Yao Lu, Ge Shen, Shu-Ling Wu, Min Chang, Cai-Qin Mu, Lei-Ping Hu, Wen-Hao Hua, Shu-Jing Song, Shu-Feng Zhang, Jun Cheng and Dao-Zhen Xu |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Yao Xie, PhD, Liver Disease Center, Beijing Ditan Hospital, Capital Medical University, 8 Jingshun East Street, Beijing 100015, China. xieyao00120184@sina.com
|
| Key Words |
Chronic hepatitis B surface antigen carriers; Inactive hepatitis B surface antigen carriers; Interferon; Peginterferon alfa-2a; Hepatitis B surface antigen loss/seroconversion |
| Core Tip |
This study examined the association between interferon (IFN) therapy and loss of hepatitis B surface antigen (HBsAg) in inactive HBsAg carriers. This was a retrospective cohort study in inactive HBsAg carriers with a serum HBsAg level < 100 IU/mL and a persis-tently undetectable hepatitis B virus (HBV) DNA level (< 100 IU/mL). All the 20 treated patients received subcutaneous PEG-IFN alfa-2a 180 μg/wk for 72 wk and were then followed for 24 wk. IFN treatment resulted in HBsAg loss (65.0%) and seroconversion in a considerable proportion of inactive HBsAg carriers with low HBsAg concentrations. In the control group, no patient experienced HBsAg loss/seroconversion, and 2 (5.0%) developed HBV reactivation.
|
| Publish Date |
2016-05-19 15:13 |
| Citation |
Li MH, Xie Y, Zhang L, Lu Y, Shen G, Wu SL, Chang M, Mu CQ, Hu LP, Hua WH, Song SJ, Zhang SF, Cheng J, Xu DZ. Hepatitis B surface antigen clearance in inactive hepatitis B surface antigen carriers treated with peginterferon alfa-2a. World J Hepatol 2016; 8(15): 637-643 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i15/637.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i15.637 |
